APOD 蛋白, Human (HEK293, C-His)

APOD Proteinas is an anti-inflammatory antagonist in the IL-1 family, targeting IL1B and IL1A to prevent immune dysregulation and systemic inflammation. Its ability to modulate inflammatory responses has important implications for potential therapeutic intervention in inflammatory diseases. APOD Protein, Human (HEK293, C-His) is the recombinant human-derived APOD protein, expressed by HEK293 , with C-10*His labeled tag. The total length of APOD Protein, Human (HEK293, C-His) is 169 a.a., with molecular weight of 25-40 kDa.

IL-1RA/IL-1RN 蛋白是 IL-1 家族中的有效抗炎拮抗剂，专门针对促炎细胞因子，例如 IL-1β/IL1B 和 IL-1α/IL1A。这种蛋白质是防止 IL1 引发的免疫失调和不受控制的全身炎症的重要保障，对包括病原体在内的各种先天刺激因子做出反应。它调节炎症反应的能力凸显了其在旨在控制炎症性疾病和维持免疫平衡的潜在治疗干预中的重要性。将焦点转向 Alpha 1-微球蛋白，它作为一种多功能抗氧化剂和组织修复剂出现，具有还原酶、血红素结合和自由基清除活性。这种蛋白质在血管内和血管外空间发挥作用，在红细胞稳态、防止血红素诱导的细胞损伤和减轻氧化应激方面发挥着关键作用。其多种功能涵盖从防止红细胞溶血到减少细胞外高铁血红蛋白以及抑制急性炎症期间低密度脂蛋白颗粒的氧化。此外，Alpha 1-微球蛋白可防止细胞外基质和细胞膜中的氧化产物，有助于细胞和细胞外基质的完整性。在细胞内环境中，它维持线粒体氧化还原稳态，提供针对血红素诱导的氧化损伤的保护，并促进内质网中正确的蛋白质折叠。此外，该蛋白具有抗蛋白酶活性，可抑制参与炎症和细胞毒性反应的关键蛋白酶，并在细胞外基质重塑和细胞粘附中发挥关键作用。

Human

HEK293

C-His

P05090 (Q21-S189)

347  [NCBI]

QAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGRCIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVTDQVNCPKLS

25-40 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 50 mM Tris-HCL, 300 mM NaCl, pH 7.4 o r20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.