ARC 蛋白, Human

ARC Protein, Human that exists in monomeric, oligomeric forms and is capable of reversible self-oligomerization. ARC Protein is a master regulator of long-term synaptic plasticity and memory^[1].

重组人 ARC (hArc) 作为单体呈金字塔形，能够可逆自缔合，形成大的可溶性寡聚体。重组人 ARC 的 N 端结构域呈高碱性，可能促进与细胞骨架结构或其他聚阴离子表面的相互作用，而 C 端结构域呈酸性，可通过促进寡聚化的离子条件保持稳定^[1]。

Human

E. coli

Tag Free

O60936 (M1-S208)

8996  [NCBI]

MGNAQERPSETIDRERKRLVETLQADSGLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRTAGAPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPGSGTTCPGLPRASDPDEAGGPEGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPEPDFEERDESEDS

Approximately 29.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, 2 mM β-ME, 20% Glycerol, pH 7.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. Craig Myrum, et al. Arc Is a Flexible Modular Protein Capable of Reversible Self-Oligomerization. Biochem J. 2015 May 15;468(1):145-58.  [Content Brief]