B2M/Beta-2 microglobulin 蛋白, Rat (99a.a, HEK293, His)

B2M or Beta-2 microglobulin binds to MHC class II protein complexes and forms homodimers. It responds to cadmium ions and exogenous stimuli and is present in the extracellular space. B2M/Beta-2 microglobulin Protein, Rat (HEK293, His) is the recombinant rat-derived B2M/Beta-2 microglobulin protein, expressed by HEK293 , with C-His labeled tag.

B2M（或 Beta-2 微球蛋白）预计具有 MHC II 类蛋白复合物结合活性和蛋白同源二聚化活性。它在对镉离子和外源刺激的反应中发挥作用，并且位于细胞外空间。B2M 可作为急性肾衰竭、肾盂肾炎和输尿管梗阻等疾病的生物标志物。该基因的人类直系同源物与多种健康状况有关，包括关节炎、家族性内脏淀粉样变性、免疫缺陷 43 和炎症性肠病。B2M 在脾、肺和其他九种组织等组织中表现出偏向表达，表明其参与多种生理过程。

Measured in a cell proliferation assay using U251 cells. ED₅₀ this effect is ≤60 ng/mL, corresponding to a specific activity is 16666.667 units/mg.

• 
  Measured in a cell proliferation assay using U251 cells. The ED₅₀ for this effect is 26.10 ng/mL, corresponding to a specific activity is 38314.1762 units/mg.

Rat

HEK293

C-His

NP_036644 (I21-M119)

24223  [NCBI]

IQKTPQIQVYSRHPPENGKPNFLNCYVSQFHPPQIEIELLKNGKKIPNIEMSDLSFSKDWSFYILAHTEFTPTETDVYACRVKHVTLKEPKTVTWDRDM

approximately 13 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.