2. 重组蛋白
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. B7-H4
  6. B7-H4 蛋白, Mouse (HEK293, His)

B7-H4 蛋白, Mouse (HEK293, His)

目录号: HY-P74394
COA 产品使用指南

B7-H4 蛋白充当负调节因子，抑制 T 细胞介导的免疫反应，包括激活、增殖、细胞因子产生和细胞毒性。当在肿瘤巨噬细胞上表达时，可以观察到显着的意义，与调节性 T 细胞 (Treg) 合作抑制肿瘤相关抗原特异性 T 细胞免疫。B7-H4 蛋白, Mouse (HEK293, His) 是重组的 B7-H4 蛋白，由 HEK293 表达，带有 C-His 标签。B7-H4 蛋白, Mouse (HEK293, His) 全长 228 个氨基酸，分子量约为 ~26.6 kDa。

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规格 价格 是否有货 数量
100 μg ￥3900 In-stock
> 100 μg   询价  

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描述

The B7-H4 protein acts as a negative regulator and inhibits T cell-mediated immune responses, including activation, proliferation, cytokine production, and cytotoxicity. Significant significance can be observed when expressed on tumor macrophages, cooperating with regulatory T cells (Tregs) to suppress tumor-associated antigen-specific T cell immunity. B7-H4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived B7-H4 protein, expressed by HEK293 , with C-His labeled tag. The total length of B7-H4 Protein, Mouse (HEK293, His) is 228 a.a., with molecular weight of ~26.6 kDa.
研究背景

B7-H4 蛋白通过抑制 T 细胞活化、增殖、细胞因子产生和细胞毒性的发展，充当 T 细胞介导的免疫反应的负调节因子。当它在肿瘤巨噬细胞的细胞表面表达时，其重要性尤其明显，它与调节性 T 细胞 (Treg) 合作，在抑制肿瘤相关抗原特异性 T 细胞免疫方面发挥着至关重要的作用。除了其免疫调节功能外，B7-H4 还参与促进上皮细胞转化，强调其参与与免疫调节和肿瘤发生相关的多种细胞过程。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

Q7TSP5 (F29-S256)
基因 ID
蛋白结构
N-term
B7-H4 (F29-S256)
Accession # Q7TSP5
His
C-term
同用名
V-set domain containing T-cell activation inhibitor 1; VTCN1; Protein B7S1; B7-H4
分子量

Approximately 26.6 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
性状

溶液
组分

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.
复溶方法

N/A.
保存条件 & 期限

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

运输条件

Shipping with dry ice.
文件资料

COA (209 KB)

产品使用指南 (1213 KB)

B7-H4 Protein, Mouse (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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