BCL2A1 蛋白, Human (His)

The BCL2A1 protein plays a critical role in resisting apoptosis triggered by IL-3 deprivation, suggesting its importance in the response of hematopoietic cells to external signals and may be involved in protecting endothelial cell survival during infection. It also inhibits serum starvation-induced apoptosis in mammary epithelial cells (HC11). BCL2A1 Protein, Human (His) is the recombinant human-derived BCL2A1 protein, expressed by E. coli , with N-His labeled tag. The total length of BCL2A1 Protein, Human (His) is 152 a.a., with molecular weight of 16-17 kDa.

BCL2A1 蛋白在延缓 IL-3 剥夺诱导的细胞凋亡中发挥着至关重要的作用，表明它参与造血细胞对外部信号的反应，并在感染期间维持内皮存活中发挥潜在作用。此外，BCL2A1 表现出抑制乳腺上皮细胞系 HC11 中血清饥饿诱导的细胞凋亡的能力。该蛋白与细胞凋亡途径中的各个关键参与者直接相互作用，包括 BAK1、BID、BMF、BBC3、BCL2L11/BIM、BAX 亚型 Sigma、PMAIP1、RTL10/BOP、ING4 和 UBQLN4。这种广泛的相互作用网络强调了 BCL2A1 在调节细胞凋亡过程中的多方面作用。

Human

E. coli

N-6*His

Q16548 (M1-S152)

597  [NCBI]

MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIKKLLRQQIAPDVDTYKEISYFVAEFIMNNTGEWIRQNGGWENGFVKKFEPKS

Approximately 16-17 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.