BCL2A1 - BCL2 related protein A1 Gene

中文名称：BCL2 相关蛋白 A1

种属: Homo sapiens

同用名: GRS; ACC1; ACC2; BFL1; ACC-1; ACC-2; HBPA1; BCL2L5

基因 ID: 597 | 基因类型: protein coding

关于 BCL2A1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:79,960,892-79,971,196 (from NCBI)

This gene has 3 transcripts (splice variants), 116 orthologues and 8 paralogues. Biased expression in bone marrow (RPKM 133.6), appendix (RPKM 46.2) and 4 other tissues.

功能概要

该基因编码 Bcl-2 蛋白家族的一个成员。该家族的蛋白质形成异源二聚体或同源二聚体，并作为抗和促凋亡调节剂参与多种细胞活动，如胚胎发育、稳态和肿瘤发生。由该基因编码的蛋白质能够减少线粒体中促凋亡细胞色素 c 的释放并阻断半胱天冬酶的激活。该基因是 NF-kappa B 响应炎症介质的直接转录靶标，并被不同的细胞外信号上调，例如粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 、CD40、佛波醇酯和炎症细胞因子 TNF 和 IL-1，这表明细胞保护功能对淋巴细胞活化和细胞存活至关重要。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block Caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCL2A1 基因产物(2)

mRNA	Protein	Name
NM_004049.4	NP_004040.1	bcl-2-related protein A1 isoform 1
NM_001114735.2	NP_001108207.1	bcl-2-related protein A1 isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10753914	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	34245648	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BCL2A1 蛋白结构

Bcl-2

0
100
175 a.a.

蛋白主名

其他名称

bcl-2-related protein A1

bcl-2-like protein 5	bcl2-L-5
hematopoietic BCL2-related protein A1	hemopoietic-specific early response protein
protein BFL-1

BCL2A1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	BCL2A1	Q16548	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
种属内	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Prey Pooling	32296183
种属内	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Validated Y2H	32296183
种属内	BCL2A1	Q16548	CT45A1	Homo sapiens	Q5HYN5	Y2H Array	32296183
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	32296183
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	25416956
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Validated Y2H	32296183
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	25416956
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Array	32296183
种属内	BCL2A1	Q16548	BAK1	Homo sapiens	Q16611	Y2H Prey Pooling	25416956
种属内	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Prey Pooling	32296183
种属内	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	Y2H Array	32296183
种属内	BCL2A1	Q16548	BCL2L11	Homo sapiens	O43521	FPS	16697956
种属内	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	32296183
种属内	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
种属内	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Y2H Array	31515488
种属内	BCL2A1	Q16548	BIK	Homo sapiens	Q13323	Validated Y2H	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 BCL2A1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75590	BCL2A1 Protein, Human (His)	Q16548 (M1-S152)	≥95%

关联疾病

疾病名称

别名

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Post-Traumatic Stress Disorder

PTSD	Traumatic Neurosis
Post Traumatic Stress Disorder	Stress Disorders, Post-Traumatic
Posttraumatic Stress Disorder	Ptsd - [Post Traumatic Stress Disorder]
Trauma-Related Disorders

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Adrenal Cortex Adenoma	Corticotroph Pituitary Adenoma
Cushing'S Disease	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Cortisone Reductase Deficiency 2

CORTRD2

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Gingival Recession

Localized Gingival Recession	Gingival Recession, Localized
Minimal Gingival Recession	Moderate Gingival Recession
Severe Gingival Recession	Gingival Recession, Minimal
Gingival Recession, Severe	Atrophy Of Gums
Gum Atrophy	Gingival Atrophy

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	纯度	Phase
HY-10969	Obatoclax Mesylate	99.74%	Phase 3
HY-N0867	13-Oxyingenol-13-dodecanoate	99.37%	Phase 3
HY-10969A	Obatoclax	≥99.0%	Phase 3
HY-15464A	(R)-(-)-Gossypol acetic acid	98.93%	Phase 2
HY-15464	(R)-(-)-Gossypol	98.82%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107738	Guggulsterone		99.95%	否
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	否
HY-P1889	Bim BH3, Peptide IV		99.35%	否
HY-132307	Mcl-1 inhibitor 6		98.40%	否
HY-P2343	BH3 hydrochloride	Activator	98.02%	否
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	否
HY-114310	VDR agonist 1		/	否
HY-135273	A-1211212		/	否
HY-19551	Apogossypolone		/	否
HY-118925	Holothurin A	Inhibitor	/	否
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	否
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	否
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	否
HY-147826	EGFR-IN-60		/	否
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	否
HY-156877	Bcl-2-IN-16		/	否
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	否
HY-161415	BCL-xL/BCL-2 ligand 1		/	否
HY-169083	Bcl-2-IN-22	Inhibitor	/	否
HY-N10481	Aviculin		/	否
HY-N3828	epi-Eriocalyxin A		/	否
HY-N8579	Eugenyl benzoate		/	否
HY-P1889A	Bim BH3, Peptide IV TFA		/	否
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	否
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	否
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	否
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	否
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	否
HY-115529	(-)BI97D6	Inducer	/	否
HY-116532	YCW-E11	Inhibitor	/	否
HY-122047	SW063058		/	否
HY-123715	Anticancer agent 255		/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	BCL2A1	VGNC	VGNC:57345
Canis familiaris	BCL2A1	VGNC	VGNC:57339
Macaca mulatta	BCL2A1	VGNC	VGNC:70242
Felis catus	BCL2A1	VGNC	VGNC:69270
Rattus norvegicus	BCL2A1	RGD	RGD:620621
Others	BCL2A1	NCBI

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