2. Anti-infection Autophagy Apoptosis
  3. HIV ULK Bcl-2 Family
  4. 13-Oxyingenol-13-dodecanoate

13-Oxyingenol-13-dodecanoate  (Synonyms: 正十二烷酸巨大戟酯)

目录号: HY-N0867
COA 产品使用指南

摩尔计算器

13-Oxyingenol-dodecanoate 是一种肿瘤抑制因子。13-Oxyingenol-dodecanoate 也具有抗 HIV-1 活性，EC50 值为 33.7 nM。13-Oxyingenol-dodecanoate 可以诱导 ULK1 表达造成线粒体功能损失和细胞自噬。13-Oxyingenol-dodecanoate 也会增加 BAX 的表达和抑制 BCL-2 的表达造成细胞凋亡。

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13-Oxyingenol-13-dodecanoate Chemical Structure

13-Oxyingenol-13-dodecanoate Chemical Structure

CAS No. : 54706-70-6

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1 mg ￥4455
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13-Oxyingenol-13-dodecanoate 相关抗体

Top Publications Citing Use of Products

查看 HIV 亚型特异性产品:

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HIV HIV-1 HIV-2

查看 ULK 亚型特异性产品:

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ULK1 ULK2

查看 Bcl-2 Family 亚型特异性产品:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC50 value of 33.7 nM[1].13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of BCL-2 to effect apoptosis[2].

体外研究
(In Vitro)

13-Oxyingenol-dodecanoate (0，3.125，6.25，12.5，25 和 50 µM，72 小时) 对降低 A549， H460 和 BEAS-2B 细胞增殖效果良好[2]。
13-Oxyingenol-dodecanoate (0，5，10 和 20 µM，72 小时) 可抑制 NSCLC 细胞中抗凋亡蛋白 BCL-2 的表达，增加促凋亡蛋白 BAX 的表达[2]。
13-Oxyingenol-dodecanoate (0，5，10 和 20 µM，72 小时) 影响细胞内的氧化还原状态，通过对线粒体膜电位丧失的影响导致 A549 和 H460 细胞中引起浓度依赖性线粒体功能障碍[2]。
13-Oxyingenol-dodecanoate (0，5，10 和 20 µM，72 小时) 诱导 ATG5 显著上调，p62 降解，LC3 I 向 LC3 II 的剂量依赖性转化，13-Oxyingenol-dodecanoate 诱导 A549 和 H460 细胞的浓度依赖性自噬[1]。
13-Oxyingenol-dodecanoate (0，5，10 和 20 µM，72 小时) 增加了 NSCLC 细胞中 ULK1的表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

13-Oxyingenol-13-dodecanoate 相关抗体:

Cell Viability Assay[2]

Cell Line: A549 and H460 cells
Concentration: 0, 3.125, 6.25, 12.5, 25, and 50 µM
Incubation Time: 72 h
Result: Increased significantly the antitumor activity of A549 and H460 cells.

Western Blot Analysis[2]

Cell Line: A549 and H460 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 72 h
Result: Induced significant up-regulation of ATG5, degradation of p62, and dose-dependent conversion of LC3 I to LC3 II.
体内研究
(In Vivo)

13-Oxyingenol-dodecanoate (2.5 mg/kg 和 5 mg/kg 腹腔注射两天一次持续 2 周) 对裸鼠皮下注射 H460 的细胞模型可明显抑制异种移植瘤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: xenograft model by injecting H460 cells into nude mice [2]
Dosage: 2.5 mg/kg and 5 mg/kg; every two days for two weeks
Administration: Intraperitoneal injection (i.p.)
Result: nhibited the growth of transplanted tumors in nude mice and had no significant toxic effects on organ function.
分子量

546.74

Formula

C32H50O7
CAS 号
性状

固体

颜色

White to off-white

中文名称

正十二烷酸巨大戟酯
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

13-Oxyingenol-13-dodecanoate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13-Oxyingenol-13-dodecanoate54706-70-6正十二烷酸巨大戟酯HIVULKBcl-2 FamilyHuman immunodeficiency virusUnc-51 like kinaseAnti-HIVNon-small cell lung cancerULK1 InducerA549 and H460 cellsInhibitorinhibitorinhibit

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