BGLAP 蛋白, Rat (GST)

BGLAP protein in its carboxylated form negatively regulates bone formation while promoting bone resorption and mineralization.The carboxylated form has a strong affinity for apatite and calcium.BGLAP Protein, Rat (GST) is the recombinant rat-derived BGLAP protein, expressed by E.coli , with N-GST labeled tag.

羧化形式的 BGLAP 蛋白在骨基质中发挥着至关重要的作用，作为骨形成的负调节剂，同时维持骨吸收和矿化。这种形式对磷灰石和钙表现出很强的结合亲和力。另一方面，未羧化形式充当成骨细胞分泌的激素，调节各种细胞过程，包括能量代谢、男性生育力和大脑发育。在能量代谢方面，它促进胰腺β细胞增殖、胰岛素分泌、胰岛素敏感性和能量消耗。此外，未羧化的骨钙素激素通过充当间质细胞上 G 蛋白偶联受体 GPRC6A 的配体，刺激睾丸中睾酮的产生，从而激活睾酮合成所需的 CREB 依赖性途径。此外，这种激素通过穿过血脑屏障并与神经元上的 GPR158 结合，充当大脑发育的调节剂。这种相互作用可以防止海马神经元凋亡，促进单胺神经递质的合成，并抑制γ-氨基丁酸（GABA）的合成。值得注意的是，骨钙素在怀孕期间也会穿过胎盘，母体骨钙素对于胎儿大脑发育是必需的。

Rat

E. coli

N-GST

P04640 (Y50-V99)

25295  [NCBI]

YLNNGLGAPAPYPDPLEPHREVCELNPNCDELADHIGFQDAYKRIYGTTV

Approximately 32.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS, 6% Trehalose, pH 7.4

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.