BLMH/Bleomycin Hydrolase 蛋白, Mouse (His)

Bleomycin Hydrolase Protein (BLMH) is crucial for cellular defense, inactivating the antitumor drug Bleomycin (BLM) by hydrolyzing its carboxamide bond. This neutralizes BLM's cytotoxic effects, protecting normal and malignant cells. BLMH's exact physiological function is unknown, but its significance in maintaining cellular balance and defending against harmful agents is evident. BLMH/Bleomycin Hydrolase Protein, Mouse (His) is the recombinant mouse-derived BLMH/Bleomycin Hydrolase Protein, expressed by E. coli , with N-His labeled tag.

BLM 水解酶，也称为博来霉素水解酶，通过催化抗肿瘤药物博来霉素 (BLM)（一种糖肽）的失活，在细胞防御机制中发挥着至关重要的作用。这种酶活性涉及 BLM 的 B-氨基丙氨酸酰胺部分内的羧酰胺键的水解，导致其失活。这个过程可以保护正常细胞和恶性细胞免受 BLM 的毒性作用。虽然 BLM 水解酶的精确生理功能尚不清楚，但其中和 BLM 细胞毒性影响的能力凸显了其在细胞稳态和防御潜在有害物质中的重要性。

Measured by its ability to hydrolyze Met-AMC and the specific activity is 368 pmols/min/ug.

Mouse

E. coli

N-His

Q8R016 (N2-E455)

104184  [NCBI]

Approximately 47 kDa.

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 50 mM Tris, 0.15M NaCl, 10% glycerol, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.