BLOC1S2 蛋白, Human

BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged. The total length of BLOC1S2 Protein, Human (GST) is 99 a.a., with molecular weight of ~11.35 KDa.

BLOC1S2 蛋白是 BLOC-1 复合物的重要组成部分，对于溶酶体相关细胞器 (LRO)（包括血小板致密颗粒和黑素体）的正常生物发生至关重要。BLOC-1 复合物与 AP-3 复合物一起，对于将膜蛋白货物引导到细胞体形成的囊泡中至关重要，从而促进它们递送到神经突和神经末梢。BLOC-1 复合物与 SNARE 蛋白结合也参与神经突延伸。作为 BORC 复合体的一部分，BLOC1S2 可能有助于溶酶体在细胞外周的运动和定位，与溶酶体的胞质面相关联，并可能招募 ARL8B 将溶酶体与微管正端定向驱动蛋白马达偶联。此外，BLOC1S2 可能在细胞增殖中发挥作用，作为溶酶体相关细胞器复合物 1 (BLOC-1) 和 BLOC-one 相关复合物 (BORC) 生物发生的一部分，与这些复合物内的各种成分相互作用，包括 BLOC1S1、 BLOC1S3、BLOC1S4、BLOC1S5、SNAPIN 和 IFT57。

Human

E. coli

Tag Free

Q6QNY1-2 (M1-R99)

282991  [NCBI]

Approximately 11.35 kDa.

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.