BNIP3L 蛋白, Human

BNIP3L, a pro-apoptotic member of the Bcl-2 family, possesses a BH3 domain and binds to Bcl-2. It directly targets mitochondria, inducing apoptotic changes like membrane potential loss and cytochrome c release. With ubiquitous expression, especially in fat and ovary, the gene suggests involvement in diverse physiological processes across multiple organs, emphasizing its potential significance. BNIP3L Protein, Human is the recombinant human-derived BNIP3L protein, expressed by E. coli , with tag free. The total length of BNIP3L Protein, Human is 186 a.a., with molecular weight of ~32-36 kDa.

BNIP3L 蛋白是 Bcl-2 家族中促凋亡亚家族的成员，具有 BH3 结构域并能够与 Bcl-2 结合。该蛋白通过直接靶向线粒体发挥促凋亡作用，导致膜电位丧失和细胞色素c释放等凋亡变化。它在细胞凋亡调节中的作用表明它参与了关键的细胞过程。该基因表现出无处不在的表达，在脂肪 (RPKM 69.4)、卵巢 (RPKM 49.9) 和 24 个其他组织中具有显着水平，强调了其在各个器官的不同生理环境中的潜在重要性。

Human

E. coli

Tag Free

NP_004322.1 (S2-K187)

665  [NCBI]

SSHLVEPPPPLHNNNNNCEENEQSLPPPAGLNSSWVELPMNSSNGNDNGNGKNGGLEHVPSSSSIHNGDMEKILLDAQHESGQSSSRGSSHCDSPSPQEDGQIMFDVEMHTSRDHSSQSEEEVVEGEKEVEALKKSADWVSDWSSRPENIPPKEFHFRHPKRSVSLSMRKSGAMKKGGIFSAEFLK

Approximately 32-36 kDa

• 
  Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from sterile 50 mM Tris-HCL, 300 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.