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  3. C-Reactive 蛋白, Cynomolgus (HEK293, His)

C-Reactive 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700979
产品使用指南

反应蛋白(CRP)执行宿主防御的多种功能,包括促进凝集、细菌荚膜肿胀、吞噬作用和补体固定。这些活性是通过其与磷酸胆碱的钙依赖性结合而促进的,表明其在协调针对病原体的免疫反应中的作用。C-Reactive 蛋白, Cynomolgus (HEK293, His) 是重组的 C-反应蛋白,由 HEK293 表达,带有 C-His 标签。C-Reactive 蛋白, Cynomolgus (HEK293, His) 全长 206 个氨基酸,分子量为 25-30 kDa。

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描述

Reactive protein (CRP) performs multiple functions of host defense, including promoting agglutination, bacterial capsule swelling, phagocytosis, and complement fixation. These activities are promoted by its calcium-dependent binding to phosphocholine, suggesting its role in orchestrating immune responses against pathogens. C-Reactive Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived C-Reactive protein, expressed by HEK293 , with C-His labeled tag. The total length of C-Reactive Protein, Cynomolgus (HEK293, His) is 206 a.a., with molecular weight of 25-30 kDa.

研究背景

反应蛋白 (CRP) 在宿主防御中发挥多方面的作用,展示了免疫反应所必需的多种功能。CRP 通过以钙依赖性方式与磷酸胆碱结合,促进凝集、细菌荚膜肿胀、吞噬作用和补体固定。此外,CRP 表现出与 DNA 和组蛋白相互作用的能力,表明其在清除受损循环细胞释放的核物质方面具有潜在作用。这些不同的功能强调了 CRP 参与免疫系统的各个方面,有助于先天性和适应性免疫反应,并强调其作为宿主防御机制中关键参与者的重要性(参考文献不可用)。

种属

Cynomolgus

表达系统

HEK293

标签

C-His

蛋白编号

XP_045255377.1 (Q19-S224)

基因 ID
蛋白结构
N-term
C-Reactive (Q19-S224)
Accession # XP_045255377.1
His
C-term
同用名
C-reactive protein; CRP; PTX1; MGC88244; pentraxin 1; PTX1MGC149895
分子量

25-30 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

C-Reactive Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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