C1D 蛋白, Human (His)

The C1D protein has multifunctionality in cellular processes, recruiting RNA exosome complexes for 5.8S rRNA processing, possibly in conjunction with MPHOSPH6. It activates PRKDC with linear and supercoiled DNA and induces apoptosis through the p53/TP53 pathway. C1D Protein, Human (His) is the recombinant human-derived C1D protein, expressed by E. coli , with N-GST labeled tag. The total length of C1D Protein, Human (His) is 141 a.a., with molecular weight of ~18 kDa.

C1D 是一种多方面的蛋白质，协调具有不同功能含义的各种细胞过程。它在将 RNA 外泌体复合物募集到 pre-rRNA 中发挥着关键作用，促进 5.8S rRNA 复杂的 3'-5' 末端加工，可能与 MPHOSPH6 合作。此外，C1D 表现出独特的激活 PRKDC 的能力，不仅在线性 DNA 存在的情况下，而且在超螺旋 DNA 存在的情况下也是如此。值得注意的是，它可以通过 p53/TP53 依赖性途径诱导细胞凋亡，显示其在程序性细胞死亡中的调节作用。此外，C1D 可以调节 TRAX/TSN 复合物的形成并增强 NR1D1 和 THRB 的转录抑制。作为分子实体，C1D 以单体和同二聚体形式存在，与一系列蛋白质相互作用，包括 NR1D1、THRA、THRB、NCOR1、NCOR2、EXOSC10、TSNAX 和 RAC3。这种复杂的相互作用网络强调了 C1D 在细胞生物学中的多样化功能和调节潜力。

Human

E. coli

N-6*His

Q13901 (M1-S141)

10438  [NCBI]

MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELLQKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITDKKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS

Approximately 18 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.