1. 重组蛋白
  2. Receptor Proteins
  3. Cell Adhesion Molecules (CAMs)
  4. Cadherins
  5. Cadherin-13
  6. Cadherin-13 蛋白, Mouse (HEK293, Fc)

Cadherin-13 蛋白, Mouse (HEK293, Fc)

目录号: HY-P74366
产品使用指南 技术支持

Cadherin-13 蛋白是钙依赖性细胞粘附分子,表现出对同质相互作用的偏好,促进相邻细胞之间的连接,并可能在细胞类型分选中发挥作用。这些蛋白质可能充当神经细胞生长的负调节因子。与经典的钙粘蛋白相反,Cadherin-13 的反式同二聚化并不是通过钙粘蛋白 EC1 结构域链交换机制发生的。相反,它是通过同质粘合界面发生的,将两个细长的 EC1-EC2 结构域靠近其 Ca2+ 结合位点聚集在一起,形成独特的四面体 X 状形状。Cadherin-13 蛋白, Mouse (HEK293, Fc) 是重组的 Cadherin-13 蛋白,由 HEK293 表达,带有 C-hFc 标签。Cadherin-13 蛋白, Mouse (HEK293, Fc) 全长 692 个氨基酸,分子量约为 ~100.6 kDa。

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描述

Cadherin-13 proteins are calcium-dependent cell adhesion molecules that exhibit a preference for homophilic interactions, fostering connections between neighboring cells and potentially playing a role in cell type sorting. These proteins may act as negative regulators of neural cell growth. In contrast to classical cadherins, the homodimerization of Cadherin-13 in trans does not occur through the cadherin EC1 domain strand-swapping mechanism. Instead, it takes place through a homophilic adhesive interface, bringing together two elongated EC1-EC2 domains in close proximity to their Ca2+-binding sites, forming a distinctive tetrahedral, X-like shape. Cadherin-13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Cadherin-13 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-13 Protein, Mouse (HEK293, Fc) is 692 a.a., with molecular weight of ~100.6 kDa.

研究背景

Cadherin-13 蛋白是钙依赖性细胞粘附分子,表现出对同质相互作用的偏好,促进相邻细胞之间的连接,并可能在细胞类型分选中发挥作用。这些蛋白质可能充当神经细胞生长的负调节因子。与经典的钙粘蛋白相反,Cadherin-13 的反式同二聚化并不是通过钙粘蛋白 EC1 结构域链交换机制发生的。相反,它是通过同质粘合界面发生的,将两个细长的 EC1-EC2 结构域靠近其 Ca2+ 结合位点聚集在一起,形成独特的四面体 X 状形状。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

Q9WTR5 (M1-A692)

基因 ID
蛋白结构
N-term
Cadherin-13 (M1-A692)
Accession # Q9WTR5
hFc
C-term
同用名
Cadherin-13; H-cadherin; T-cadherin; T-cad; CDH13
分子量

Approximately 100.6 kDa

纯度

Greater than 80% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

Cadherin-13 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
Cadherin-13 Protein, Mouse (HEK293, Fc)
目录号:
HY-P74366
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