2. 重组蛋白
  3. Receptor Proteins
  4. Cell Adhesion Molecules (CAMs)
  5. Cadherins
  6. LI-Cadherin/Cadherin-17
  7. Cadherin-17 蛋白, Cynomolgus (HEK293, Fc)

Cadherin-17 蛋白, Cynomolgus (HEK293, Fc)

目录号: HY-P77309
产品使用指南

Cadherin-17 蛋白是钙依赖性细胞粘附蛋白家族的成员，在介导细胞粘附中发挥着至关重要的作用。Cadherin-17 采用优先同源相互作用，促进连接细胞之间的自结合。凭借其钙依赖性粘附特性，Cadherin-17 积极参与建立细胞之间的选择性连接，影响细胞相互作用的动态调节，并有助于组织 (特别是肝脏和肠道) 的整体结构完整性。Cadherin-17 蛋白, Cynomolgus (HEK293, Fc) 是重组的 钙粘蛋白 17 蛋白，由 HEK293 表达，带有 C-hFc 标签。Cadherin-17 蛋白, Cynomolgus (HEK293, Fc) 全长 787 个氨基酸，分子量约为 ~111.8 KDa。

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描述

Cadherin-17 Protein, a member of the calcium-dependent cell adhesion protein family, assumes a crucial role in mediating cellular adhesion. Employing preferential homophilic interactions, Cadherin-17 facilitates self-binding between connecting cells. With its calcium-dependent adhesion properties, Cadherin-17 actively participates in establishing selective connections between cells, influencing the dynamic regulation of cellular interactions and contributing to the overall structural integrity of tissues, particularly in the liver and intestine. Cadherin-17 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Cadherin-17 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Cadherin-17 Protein, Cynomolgus (HEK293, Fc) is 787 a.a., with molecular weight of ~111.8 KDa.
研究背景

Cadherin-17 是钙依赖性细胞粘附蛋白家族的成员，在介导细胞粘附中发挥着至关重要的作用。Cadherin-17 采用优先同源相互作用，促进连接细胞之间的自结合。这种同质钙粘蛋白的结合强调了它在细胞粘附中的重要性，并表明它对异质细胞类型的复杂分选过程做出了重大贡献。此外，Cadherin-17 也称为 LI-cadherin，可能在肝脏和肠道的形态组织中发挥作用，表明它参与这些组织的结构组织。凭借其钙依赖性粘附特性，Cadherin-17 积极参与建立细胞之间的选择性连接，影响细胞相互作用的动态调节，并有助于组织 (特别是肝脏和肠道) 的整体结构完整性[1]。
种属

Cynomolgus
表达系统

HEK293
标签

C-hFc
蛋白编号

XP_005563762 (M1-M787)
基因 ID

102129651  [NCBI]
蛋白结构
N-term
Cadherin-17 (M1-M787)
Accession # XP_005563762
hFc
C-term
同用名
Cadherin-17; CDH17; Intestinal Peptide-Associated Transporter HPT-1
分子量

Approximately 111.8 kDa.
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Cadherin-17 Protein, Cynomolgus (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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