CADM1/IGSF4A 蛋白, Mouse (HEK293, His)

CADM1/IGSF4A proteins coordinate Ca(2+)-independent homophilic and heterophilic cell adhesion with CADM3 and NECTIN3. Interaction with CRTAM enhances NK cell cytotoxicity and CD8+ T cell function. CADM1/IGSF4A Protein, Mouse (341a.a, HEK293, His) is the recombinant mouse-derived CADM1/IGSF4A protein, expressed by HEK293 , with C-6*His labeled tag.

多项研究证实，CADM1/IGSF4A 蛋白以不依赖 Ca(2+) 的方式协调同质细胞间粘附。此外，它与 CADM3 和 NECTIN3 进行异嗜性细胞间粘附，与钙水平无关。它与 CRTAM 的相互作用不仅促进自然杀伤 (NK) 细胞的细胞毒性和 CD8+ T 细胞分泌干扰素 (IFN-gamma)，而且还促进 NK 细胞介导的体内表达 CADM1 肿瘤的排斥反应。在肥大细胞中，CADM1可能在神经的附着和通讯中发挥作用，对于体内肥大细胞的发育和生存是不可或缺的。该蛋白的作用延伸到调节引流淋巴结内活化的 CD8+ T 细胞的保留，并影响上皮内 CD4+ CD8+ T 细胞的肠道保留。此外，CADM1 作为突触细胞粘附分子，有助于树突棘形成和突触组装，同时可能影响神经元迁移、轴突生长、寻路和束颤。它的多种作用还包括参与精子发生，包括精母细胞和精子细胞与支持细胞的粘附以及它们分化为成熟精子。CADM1 相互作用的复杂网络涉及同二聚化，以及与 FARP1、CRTAM、EPB41L3/DAL1、MPP2、MPP3 和 PALS2 的关联，为理解其多方面贡献提供了一个全面的框架。

Mouse

HEK293

C-6*His

Q8R5M8-1 (Q48-H388)

54725  [NCBI]

QNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDH

60-100 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.