CALM2 蛋白, Human (His)

The CALM2 protein is an important component of calcium signaling, controlling enzymes, ion channels, and aquaporins through calcium binding. CALM2 Protein, Human (His) is the recombinant human-derived CALM2 protein, expressed by E. coli , with N-His labeled tag. The total length of CALM2 Protein, Human (His) is 149 a.a., with molecular weight of ~19 kDa.

CALM2（钙调蛋白 2）是钙信号转导途径的关键组成部分，通过其钙结合能力在众多酶、离子通道、水通道蛋白和其他蛋白质的调节中发挥着关键作用。钙调蛋白的激活取决于钙结合，使其能够控制各种细胞过程。值得注意的是，钙调蛋白-钙复合物会刺激一系列酶，包括肌球蛋白轻链激酶和钙调蛋白依赖性蛋白激酶 II 型 (CaMK2) 以及磷酸酶。CALM2 与 CCP110 和中心蛋白一起参与控制中心体周期和胞质分裂进程的遗传途径。此外，CALM2 介导 CACNA1C 的钙依赖性失活，并正向调节 KCNN2 的钙激活钾通道活性。此外，在微生物感染的情况下，C.violaceum CopC 的精氨酸 ADP-核糖酶活性需要 CALM2。这些多方面的功能强调了 CALM2 在协调细胞对钙信号的反应中的不可或缺的作用。

Human

E. coli

N-His

P0DP24 (M1-K149)

801  [NCBI]

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Approximately 19 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.