Carbonic Anhydrase 2 蛋白, Human (C-His, Solution)

Carbonic Anhydrase 2 (CA2) catalyzes the reversible hydration of carbon dioxide. Mutations in CA2 are linked to osteopetrosis and renal tubular acidosis. The gene exhibits biased expression in various tissues, notably in the stomach and colon. Two transcript variants, encoding different isoforms, have been identified. Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is the recombinant human-derived Carbonic Anhydrase 2 protein, expressed by E. coli , with C-His labeled tag. The total length of Carbonic Anhydrase 2 Protein, Human (C-His, Solution) is 259 a.a., with molecular weight of ~30 kDa.

碳酸酐酶 2 蛋白是碳酸酐酶同工酶家族的成员，负责催化二氧化碳的可逆水合。这种酶的失调与骨硬化症和肾小管酸中毒等疾病有关。已鉴定出编码不同亚型的两种转录变体。除了在二氧化碳代谢中的基本作用外，该蛋白还在各种组织中表现出偏向表达，其中在胃和结肠以及其他八个组织中表达水平显着。这种组织特异性表达谱表明，除了其在酸碱平衡中的既定功能之外，它还可能参与专门的生理过程。

Measured by its esterase activity and the specific activity is >150 pmoles/min/μg.

Human

E. coli

C-His

NP_000058.1 (S2-K260)

760  [NCBI]

MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK

Approximately 30 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of 20 mM Tris 0.5M NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.