Cardiotrophin-1/CTF1 蛋白, Human (HEK293, Fc)

Cardiotrophin-1/CTF1 protein induces cardiac myocyte hypertrophy in vitro by binding to and activating the ILST/gp130 receptor, highlighting its regulatory role in heart muscle cell enlargement. This engagement orchestrates signaling events that contribute to the hypertrophic response, providing insight into the mechanisms of cardiac hypertrophy and implicating Cardiotrophin-1 in heart muscle growth. Cardiotrophin-1/CTF1 Protein, Human (HEK293, Fc) is the recombinant human-derived Cardiotrophin-1/CTF1 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Cardiotrophin-1/CTF1 Protein, Human (HEK293, Fc) is 200 a.a., with molecular weight of 54 & 37 kDa, respectively.

Cardiotropin-1/CTF1 蛋白在体外是心肌细胞肥大的有效诱导剂，强调了其在心肌细胞增大中的调节作用。这种效应是通过其与 ILST/gp130 受体的结合和激活介导的，表明 Cardiotropin-1 通过特定的分子途径发挥其影响。通过与 ILST/gp130 受体结合，Cardiotropin-1 协调信号事件，促进心肌细胞肥大反应。对 Cardiotropin-1 及其受体之间相互作用的分子洞察提供了对心脏肥大机制的基础了解，并表明该蛋白质与心肌生长的调节有关。

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells and the ED₅₀ is typically 0.015-0.06 μg/mL.

Human

HEK293

N-hFc

Q16619 (S2-A201)

1489  [NCBI]

SRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA

54&37 kDa

Greater than 80% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.