1. 重组蛋白
  2. Cytokines and Growth Factors Receptor Proteins
  3. Chemokine & Receptors G-Protein-Coupled Receptors (GPCRs)
  4. CC Chemokine Receptor Chemokine Receptor
  5. CCR4
  6. CCR4 蛋白, Human (Cell-Free, His)

CCR4 蛋白, Human (Cell-Free, His)

目录号: HY-P702606
产品使用指南 技术支持

CCR4 蛋白-VLP 是一种多功能实体,充当 CC 型趋化因子的高亲和力受体,并特异性结合 CCL17/TARC、CCL22/MDC 和 CKLF1。它通过 G(i) 蛋白介导趋化反应并激活磷脂酰肌醇-钙第二信使系统。CCR4 蛋白, Human (Cell-Free, His) 是重组的 CCR4 蛋白,由 E. coli Cell-free 表达,带有 N-10*His 标签。CCR4 蛋白, Human (Cell-Free, His) 全长 360 个氨基酸

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描述

CCR4 protein-VLP is a multifunctional entity that acts as a high-affinity receptor for CC-type chemokines and specifically binds CCL17/TARC, CCL22/MDC, and CKLF1. It mediates chemotactic responses through G(i) protein and activates the phosphatidylinositol-calcium second messenger system. CCR4 Protein, Human (Cell-Free, His) is the recombinant human-derived CCR4, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of CCR4 Protein, Human (Cell-Free, His) is 360 a.a.,

研究背景

CCR4 蛋白-VLP 是一种多功能实体,作为 CC 型趋化因子的高亲和力受体而脱颖而出,特别表现出对 CCL17/TARC、CCL22/MDC 和 CKLF 亚型 1/CKLF1 的结合亲和力。其功能范围延伸至通过 G(i) 蛋白介导趋化反应,从而激活磷脂酰肌醇-钙第二信使系统。除了作为循环记忆淋巴细胞上的趋化归巢受体的作用之外,CCR4 蛋白-VLP 还可以作为某些原发性 HIV-2 分离株的辅助受体。有趣的是,在中枢神经系统(CNS)中,它有可能介导海马神经元的存活,为其多方面的功能增添了一层复杂性。

种属

Human

表达系统

E. coli Cell-free

标签

N-10*His

蛋白编号

P51679 (M1-L360)

基因 ID

1233

同用名
CCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD antigen CD194
分子量

44.9 kDa

纯度

Greater than 90 % as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CCR4 Protein, Human (Cell-Free, His)
目录号:
HY-P702606
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