ICAM-2/CD102 蛋白, Human (HEK293, His)

ICAM-2/CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.

ICAM-2 (CD102) 与结构相关的 ICAM-1 (CD54) 和 ICAM-3 (CD50) 蛋白一样，是白细胞整联蛋白 ß2 家族的已知配体。这些包括 CD11a/CD18 (LFA-1)、CD11b/CD18 (Mac-1) 和树突状细胞特异性 ICAM 捕获非整合素 (DC-SIGN) 蛋白。ICAM-2 包含两个免疫球蛋白结构域，它们与 ICAM-1 的第一和第二免疫球蛋白结构域同源，没有任何已知的剪接变体。ICAM-2 均匀存在于骨髓细胞悬液中所有 B 淋巴细胞谱系细胞亚群上。血管内皮细胞上的高水平组成型表达以及对炎症刺激的反应性比ICAM-1低也是ICAM-2的特征。重组ICAM-2可以在体外共刺激T细胞。尽管 ICAM-2 介导中性粒细胞迁移，但 ICAM-2 似乎能够介导不依赖于 CD31/PECAM-1 的白细胞迁移。ICAM-2 还可能通过多种机制调节血管生成，包括存活、细胞迁移和 Rac 激活^[1][2]。

Human

HEK293

C-6*His

P13598 (K25-Q223)

3384  [NCBI]

KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQHHHHHH

Approximately 43 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.

• [1]. Yoshio Yamashita, et al. Participation of intercellular adhesion molecule-2 (CD102) in B lymphopoiesis. Immunol Lett. 2008 Oct 30;120(1-2):79-86.  [Content Brief]

  [2]. Ruth Lyck, et al. The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues. Curr Opin Hematol. 2015 Jan;22(1):53-9.  [Content Brief]