1. Gene
  2. ICAM2 - intercellular adhesion molecule 2 Gene

ICAM2 - intercellular adhesion molecule 2 Gene

中文名称:细胞间粘附分子 2

种属: Homo sapiens

同用名: CD102

基因 ID: 3384 | 基因类型: protein coding

关于 ICAM2

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:64,002,595-64,020,633 (from NCBI)

This gene has 16 transcripts (splice variants), 105 orthologues and 4 paralogues. Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues.

功能概要

该基因编码的蛋白质是细胞间粘附分子 (ICAM) 家族的成员。所有 ICAM 蛋白都是 I 型跨膜糖蛋白,包含 2-9 个免疫球蛋白样 C2 型结构域,并与白细胞粘附 LFA-1 蛋白结合。这种蛋白质可能通过阻断 LFA-1 依赖性细胞粘附在淋巴细胞再循环中发挥作用。它介导对抗原特异性免疫反应很重要的粘附相互作用、NK 细胞介导的清除、淋巴细胞再循环,以及对免疫反应和监视很重要的其他细胞相互作用。已发现该基因的几种转录变体编码相同的蛋白质。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ICAM2 基因产物(5)

mRNA Protein Name
NM_000873.4 NP_000864.2 intercellular adhesion molecule 2 precursor
NM_001099786.2 NP_001093256.1 intercellular adhesion molecule 2 precursor
NM_001099787.2 NP_001093257.1 intercellular adhesion molecule 2 precursor
NM_001099788.2 NP_001093258.1 intercellular adhesion molecule 2 precursor
NM_001099789.2 NP_001093259.1 intercellular adhesion molecule 2 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
1448173 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cleavage furrow IDA
IDA: 通过直接分析推断
19799413 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ICAM2 蛋白结构

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (24 - 114)

  • 0
  • 100
  • 200
  • 275 a.a.
蛋白主名 其他名称

intercellular adhesion molecule 2

ICAM-2

重组 ICAM2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7775 ICAM-2/CD102 Protein, Human (HEK293, His) P13598 (K25-Q223) ≥95%
HY-P73115 ICAM-2/CD102 Protein, Human (HEK293, His-Fc) Q6FHE2/NP_000864.2 (K25-Q223) ≥95%
HY-P73116 ICAM-2/CD102 Protein, Human (HEK293, His, solution) Q6FHE2 (S22-Q223) ≥95%

关联疾病

疾病名称 别名
Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency 1

LAD1

Lad

Lymphocyte Function-Associated Antigen 1 Immunodeficiency

Leukocyte Adhesion Deficiency Type I

Leukocyte Adhesion Deficiency Type 1

Linear Iga Bullous Dermatosis

Linear Iga Dermatosis

Leukocyte-Adhesion Deficiency Syndrome

Lfa1 Immunodeficiency

Congenital Leukocyte Adherence Deficiency

Lad-I

Linear Iga Disease

Leukocyte Adhesion Deficiency Syndrome

Lad 1

Lfa 1 Immunodeficiency

Linear Immunoglobulin A Dermatosis

Leucocyte Adhesion Deficiency Type 1

Leukocyte Adhesion Molecule Deficiency Type 1

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ
Polyarteritis Nodosa

Polyarteritis

Periarteritis Nodosa

Pan

Periarteritis

Kussmaul-Maier Disease

Panarteritis Nodosa

Kussmaul Disease

Pan - [Polyarteritis Nodosa]

Polyangiitis

Panangiitis

Arteritis Nodosa

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ICAM2 VGNC VGNC:73552
Canis familiaris ICAM2 VGNC VGNC:55612
Mus musculus ICAM2 MGD MGI:96394
Rattus norvegicus ICAM2 RGD RGD:1359660
Others ICAM2 NCBI