CD105/Endoglin 蛋白, Mouse (HEK293, His)

CD105/Endoglin is an important endothelial glycoprotein that controls angiogenesis and ensures the structural integrity of the adult vasculature. It affects vascular endothelial cell migration and has important implications for extraembryonic and embryonic heart development. CD105/Endoglin Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD105/Endoglin protein, expressed by HEK293 , with C-His labeled tag. The total length of CD105/Endoglin Protein, Mouse (HEK293, His) is 554 a.a., with molecular weight of 65-70 kDa.

CD105/Endoglin 是一种血管内皮糖蛋白，在血管生成调节中发挥着至关重要的作用，有助于成人脉管系统的正常结构和完整性。CD105/Endoglin 对于维持脉管系统的结构完整性至关重要，还影响血管内皮细胞的迁移。其重要性延伸至胚胎外血管生成和胚胎心脏发育，强调了其在血管发育中的重要作用。CD105/Endoglin 可以调节内皮细胞对血流的反应，影响血管重塑和血管生成过程中正常血管形态的建立。作为 TGF-β 辅助受体，它参与 TGF-β/BMP 信号级联，导致 SMAD 转录因子的激活。此外，CD105/Endoglin 与多种分子相互作用，包括 TGFB1、GDF2、ACVRL1、BMP10、DYNLT4 和 ARRB2，突显其在细胞过程中的多方面参与。该蛋白通过二硫键形成同二聚体，并与 TGF-β 信号受体形成异聚复合物。此外，CD105/Endoglin 以高亲和力结合 TGFB1 和 TGFB2，进一步强调了其在分子相互作用中的复杂作用。

Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. The ED₅₀ for this effect is typically 25-100 ng/mL in the presence of 2 ng/mL of recombinant human BMP9.

Mouse

HEK293

C-His

Q63961 (R28-G581)

13805  [NCBI]

MDRGVLPLPITLLFVIYSFVPTTGLAERVGCDLQPVDPTRGEVTFTTSQVSEGCVAQAANAVREVHVLFLDFPGMLSHLELTLQASKQNGTETQEVFLVLVSNKNVFVKFQAPEIPLHLAYDSSLVIFQGQPRVNITVLPSLTSRKQILDWAATKGAITSIAALDDPQSIVLQLGQDPKAPFLCLPEAHKDMGATLEWQPRAQTPVQSCRLEGVSGHKEAYILRILPGSEAGPRTVTVMMELSCTSGDAILILHGPPYVSWFIDINHSMQILTTGEYSVKIFPGSKVKGVELPDTPQGLIAEARKLNASIVTSFVELPLVSNVSLRASSCGGVFQTTPAPVVTTPPKDTCSPVLLMSLIQPKCGNQVMTLALNKKHVQTLQCTITGLTFWDSSCQAEDTDDHLVLSSAYSSCGMKVTAHVVSNEVIISFPSGSPPLRKKVQCIDMDSLSFQLGLYLSPHFLQASNTIELGQQAFVQVSVSPLTSEVTVQLDSCHLDLGPEGDMVELIQSRTAKGSCVTLLSPSPEGDPRFSFLLRVYMVPTPTAGTLSCNLALRPSTLSQEVYKTVSMRLNIVSPDLSGKG

65-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.