2. Gene
  3. Eng - endoglin Gene

Eng - endoglin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Endo; CD105; S-endoglin

基因 ID: 13805 | 基因类型: protein coding

关于 Eng

功能概要

Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of gene expression. Acts upstream of or within circulatory system development and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including brain; cardiovascular system; extraembryonic vascular system; and lung. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin). [provided by Alliance of Genome Resources, Apr 2022]

Eng 基因产物(3)

mRNA Protein Name
NM_001146348.1 NP_001139820.1 endoglin isoform 3 precursor
NM_001146350.1 NP_001139822.1 endoglin isoform 2 precursor
NM_007932.2 NP_031958.2 endoglin isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23868260 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
8194490 MGI
enables transforming growth factor beta binding IDA
IDA: 通过直接分析推断
8194490 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within angiogenesis IMP
IMP: 通过突变表型推断
10625534 MGI
involved in artery morphogenesis IMP
IMP: 通过突变表型推断
10348742 MGI
involved in atrial cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
17628518 MGI
involved in atrioventricular canal morphogenesis IMP
IMP: 通过突变表型推断
19703439 MGI
involved in branching involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
10348742 MGI
involved in cardiac atrium morphogenesis IMP
IMP: 通过突变表型推断
19703439 MGI
NOT involved in cardiac jelly development IMP
IMP: 通过突变表型推断
19703439 MGI
involved in cardiac ventricle morphogenesis IMP
IMP: 通过突变表型推断
19703439 MGI
acts upstream of or within cell migration involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
19703439 MGI
involved in dorsal aorta morphogenesis IMP
IMP: 通过突变表型推断
12941632 MGI
involved in endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
12941632 MGI
NOT involved in endocardial cushion to mesenchymal transition IMP
IMP: 通过突变表型推断
12941632 MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
19703439 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
10562296 MGI
involved in heart looping IMP
IMP: 通过突变表型推断
10348742 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
12941632 MGI
involved in outflow tract septum morphogenesis IGI
IGI: 通过遗传相互作用推断
17628518 MGI
acts upstream of or within positive regulation of angiogenesis IGI
IGI: 通过遗传相互作用推断
23868260 MGI
involved in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
19703439 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
19703439 MGI
involved in positive regulation of vascular associated smooth muscle cell differentiation IMP
IMP: 通过突变表型推断
17628518 MGI
NOT involved in regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
17628518 MGI
NOT involved in regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
17628518 MGI
NOT involved in regulation of cell proliferation involved in heart morphogenesis IMP
IMP: 通过突变表型推断
17628518 MGI
involved in smooth muscle tissue development IMP
IMP: 通过突变表型推断
10348742 MGI
NOT involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
19703439 MGI
involved in vascular associated smooth muscle cell development IMP
IMP: 通过突变表型推断
17628518 MGI
acts upstream of or within vasculogenesis IMP
IMP: 通过突变表型推断
10562296 MGI
involved in vasculogenesis IMP
IMP: 通过突变表型推断
10348742 MGI
involved in venous blood vessel morphogenesis IMP
IMP: 通过突变表型推断
10348742 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: 通过突变表型推断
19703439 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endothelial microparticle IDA
IDA: 通过直接分析推断
20978343 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

endoglin

cell surface MJ7/18 antigen

transmembrane glycoprotein

重组 Eng 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75446 CD105/Endoglin Protein, Mouse (HEK293, His) Q63961 (R28-G581) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04374 ENG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Eng NCBI NCBI:2022
Rattus norvegicus Eng NCBI NCBI:497010
Macaca mulatta Eng NCBI NCBI:706569
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