CD131 蛋白, Human (HEK293, His)

The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Human (HEK293, His) is the recombinant human-derived CD131 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD131 Protein, Human (HEK293, His) is 427 a.a., with molecular weight of 50-55 kDa.

CD131 是一种细胞表面受体，通过控制造血祖细胞向谱系限制细胞的产生和分化，在免疫反应中发挥关键作用。通过与各种伙伴（例如 IL3RA、IL5RA 或 CSF2RA）形成异二聚体受体，CD131 参与多种信号传导途径，包括白细胞介素 3、白细胞介素 5 和粒细胞巨噬细胞集落刺激因子/CSF2 途径。在未刺激的条件下，CD131 与 JAK1 持续相互作用，配体结合导致 JAK1 刺激，从而触发 JAK-STAT 通路的激活。CD131 形成由 α 和 β 亚基组成的异二聚体，其中 β 亚基是 IL3、IL5 和 GM-CSF 受体共有的。参与信号传导的 GM-CSF 受体复合物是一个十二聚体，由两个 α、两个 β 和两个配体亚基的两个头对头六聚体组成。CD131 进一步与 TMEM102、FCER1G、LYN 和 JAK1 相互作用，从而在细胞反应中发挥复杂的作用。

Human

HEK293

C-His

P32927 (W17-W443)

1439  [NCBI]

50-55 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.