1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins
  4. PSGL-1/CD162
  5. CD162/PSGL-1 蛋白, Cynomolgus (HEK293, His)

CD162/PSGL-1 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700815
产品使用指南

CD162/PSGL-1 作为选择素家族的一员,主要表达于一些免疫或炎症细胞中。CD162/PSGL-1 缺乏影响髓细胞分化和淋巴细胞成熟,因此在细胞分化中具有重要意义。CD162/PSGL-1 可作为免疫检查点调节剂,可能成为癌症治疗的新靶点。CD162/PSGL-1 蛋白, Cynomolgus (HEK293, His) 是重组的 CD162/PSGL-1 蛋白,由 HEK293 表达,带有 C-His 标签。CD162/PSGL-1 蛋白, Cynomolgus (HEK293, His) 全长 323 个氨基酸,分子量为 72-82 kDa。

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描述

As a member of the selectin family, CD162/PSGL-1 is mainly expressed in some immune or inflammatory cells. CD162/PSGL-1 deficiency affects myeloid differentiation and lymphocyte maturation and therefore has important implications for cell differentiation. CD162/PSGL-1 can be used as an immune checkpoint modulator and may be a new target for cancer therapy. CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD162/PSGL-1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) is 323 a.a., with molecular weight of 72-82 kDa.

研究背景

选择素 P 配体,又称 SELPLG 或 CD162,是髓细胞和受刺激 T 淋巴细胞上 P-选择素的高亲和力拮抗受体。SELPLG 作为选择素家族的一员,主要表达于一些免疫或炎症细胞中。SELPLG 缺乏影响髓细胞分化和淋巴细胞成熟,因此在细胞分化中具有重要意义。SELPLG 可作为免疫检查点调节剂,可能成为癌症治疗的新靶点。

种属

Cynomolgus

表达系统

HEK293

标签

C-His

蛋白编号

A0A7N9CVJ8 (L34-C356)

基因 ID

102142477

蛋白结构
N-term
PSGL-1 (L34-C356)
Accession # A0A7N9CVJ8
His
C-term
同用名
CLA; PSGL-1; PSGL1; CD162; SELPLG; Selectin P ligand; Selp1; Selpl
分子量

72-82 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

CD162/PSGL-1 Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD162/PSGL-1 Protein, Cynomolgus (HEK293, His)
目录号:
HY-P700815
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