2. 重组蛋白
  3. CAR-T related Proteins CD Antigens Biotinylated Proteins
  4. CD19 B Cell CD Proteins Stem Cell CD Proteins Dendritic Cell CD Proteins
  5. CD19 蛋白, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)

CD19 蛋白, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)

目录号: HY-P76857
产品使用指南

CD19 是 B 细胞受体复合物的信号传导成分，能够降低抗原驱动激活的阈值。CD19 蛋白, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) 是重组的 CD19 蛋白，由 HEK293 表达，带有 C-His 标签。CD19 蛋白, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) 全长 272 个氨基酸，分子量约为 ~31.4 KDa。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CD19 is a signaling component of the B-cell receptor complex that lowers the threshold for antigen-driven activation. CD19 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) is the recombinant Rhesus Macaque-derived CD19 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD19 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) is 272 a.a., with molecular weight of ~31.4 KDa.
研究背景

CD19 是 B 细胞受体复合物的信号传导成分，是通过降低抗原驱动激活的阈值来驱动 B 细胞分化和生发中心 (GC) 形成的调节因子。CD19 可多种膜蛋白（包括补体受体 2 型 (CD21) 和四跨膜蛋白 (CD81)）形成复合物，从而降低抗原引发的 B 细胞激活的阈值。随后，CD19 复合物将激活磷脂酰肌醇 3-激酶信号通路，并随后释放细胞内储存的钙离子。CD19 被用于治疗淋巴细胞白血病的嵌合抗原受体 (CAR) T 细胞。抗 CD19 CAR-T 细胞法已被用于治疗 B 细胞恶性肿瘤，并在 B 细胞激活失调的系统性红斑狼疮 (SLE) 中发挥关键作用。CD19 还与冠状病毒有生物学关系，可能参与有关免疫反应或抗病毒活性。
种属

Rhesus Macaque
表达系统

HEK293
标签

C-His
蛋白编号

F7F486 (Q21-K292)
基因 ID
蛋白结构
N-term
CD19 (Q21-K292)
Accession # F7F486
His
C-term
同用名
B-lymphocyte antigen CD19; CD19; B-lymphocyte surface antigen B4
分子量

Approximately 31.4 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD19 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
CD19 Protein, Cynomolgus/Rhesus Macaque (Biotinylated, HEK293, His)
目录号：
HY-P76857
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z