CD200R1 蛋白, Cynomolgus (HEK293, His)

CD200R1 Protein is an Ig superfamily transmembrane glycoprotein expressed on the surface of myeloid cells. CD200R1 Protein can also be induced in certain T-cell subsets. CD200R1 signaling inhibits the expression of proinflammatory molecules^[1]. CD200R1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD200R1 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD200R1 Protein, Cynomolgus (HEK293, His) is 221 a.a., with molecular weight of 43-75 KDa.

CD200R1 是表达于骨髓细胞表面的 Ig 超家族跨膜糖蛋白；它也可以在某些 T 细胞亚群中被诱导。CD200R1 与 CD200（也是一种 Ig 超家族跨膜糖蛋白）相互作用，下调骨髓细胞功能。CD200在多种细胞的表面表达，包括神经元、上皮细胞、内皮细胞、成纤维细胞、淋巴细胞和星形胶质细胞。CD200R1 信号传导的调节可以通过翻译后修饰（即 CD200R1 细胞质尾部中的酪氨酸磷酸化）或通过 CD200R1 或 CD200 的诱导表达或下调来发生。CD200:CD200R1 抑制信号通路在限制多种炎症性疾病的炎症方面发挥着重要作用。CD200R1 信号传导会响应选定的刺激而抑制促炎分子的表达，包括肿瘤坏死因子、干扰素和诱导型一氧化氮合酶^[1]。

1.Immobilized Cynomolgus CD200R at 2 μg/mL (100 μL/well) can bind Rhesus macaque CD200. The ED₅₀ for this effect is 9.602 ng/mL.
2.Immobilized Cynomolgus CD200R at 0.5 μg/mL (100 μL/well) can bind Rhesus macaque CD200. The ED₅₀ for this effect is ≤24 ng/mL.

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  Immobilized Cynomolgus CD200R at 2 μg/mL (100 μL/well) can bind Rhesus macaque CD200. The ED₅₀ for this effect is 9.602 ng/mL.

Cynomolgus

HEK293

C-His

XP_005548207.1 (S47-L267)

102139962  [NCBI]

SNSLCMDEKQITQNHSKVLAEVNISWPVQMARNAVLCCPPIEFRNLIVITWEIILRGQPSCTKTYRKDTNETKETNCTDERITWVSTPDQNSDLQIHPVAITHDGYYRCIMATPDGNFHRGYHLQVLVTPEVTLFESRNRTAVCKAVAGKPAAQISWIPAGDCAPTEQEYWGNGTVTVKSTCHWEGHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKL

Approximately 43-75 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.