1. 重组蛋白
  2. Immune Checkpoint Proteins CAR-T related Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Epithelial cell CD Proteins
  4. B7-H3 B7-H3/CD276
  5. CD276/B7-H3 蛋白, Human (217a.a, HEK293, Fc)

CD276/B7-H3 蛋白, Human (217a.a, HEK293, Fc)

目录号: HY-P77578
产品使用指南

CD276/B7-H3蛋白可以调节T细胞介导的免疫反应,并通过抑制自然杀伤介导的细胞裂解作为肿瘤细胞的保护因子。它还充当神经母细胞瘤细胞标记物,在急性和慢性移植排斥中发挥作用,并调节粘膜表面的淋巴细胞活性。CD276/B7-H3 蛋白, Human (217a.a, HEK293, Fc) 是重组的 CD276/B7-H3 蛋白,由 HEK293 表达,带有 C-hFc 标签。CD276/B7-H3 蛋白, Human (217a.a, HEK293, Fc) 全长 217 个氨基酸,分子量为 60-70 kDa。

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描述

CD276/B7-H3 protein can regulate T cell-mediated immune responses and act as a protective factor for tumor cells by inhibiting natural killer-mediated cell lysis. It also functions as a neuroblastoma cell marker, plays a role in acute and chronic transplant rejection, and modulates lymphocyte activity at mucosal surfaces. CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) is the recombinant human-derived CD276/B7-H3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) is 217 a.a., with molecular weight of 60-70 kDa.

研究背景

CD276/B7-H3 蛋白被认为在调节 T 细胞介导的免疫反应中发挥多方面的作用,通过抑制自然杀伤介导的细胞裂解,潜在地充当肿瘤细胞的保护因子,并作为肿瘤细胞的标记物。神经母细胞瘤细胞的检测。此外,CD276/B7-H3 可能参与急性和慢性移植排斥的发生,有助于调节粘膜表面的淋巴细胞活性。值得注意的是,它在整个怀孕期间为胎盘和胎儿提供适宜的免疫环境方面发挥着至关重要的作用。CD276/B7-H3 的亚型 1 和亚型 2 在调节 CD4 T 细胞反应的能力上似乎都是多余的,亚型 2 被证明可以增强细胞毒性 T 细胞的诱导,并在 T 存在的情况下选择性刺激干扰素 γ 的产生。-细胞受体信号传导。与 TREML2 的相互作用被确定为增强 T 细胞激活,突显了 CD276/B7-H3 在免疫调节和细胞反应中可能发挥的不同作用。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

Q5ZPR3-2 (L29-P245)

基因 ID
蛋白结构
N-term
CD276 (L29-P245)
Accession # Q5ZPR3-2
hFc
C-term
同用名
B7H3; B7-H3; CD276; PSEC0249;  UNQ309; PRO352; B7 homolog 3; CD276
分子量

60-70 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc)
目录号:
HY-P77578
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