2. Gene
  3. CD276 - CD276 molecule Gene

CD276 - CD276 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD276 分子

种属: Homo sapiens

同用名: B7H3; B7-H3; B7RP-2; 4Ig-B7-H3

基因 ID: 80381 | 基因类型: protein coding

关于 CD276

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,683,944-73,714,514 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues.

功能概要

该基因编码的蛋白质属于免疫球蛋白超家族，被认为参与调节 T 细胞介导的免疫反应。研究表明，虽然该基因的转录本在正常组织和实体瘤中普遍表达，但该蛋白仅优先在肿瘤组织中表达。此外，观察到该转录物的 3' UTR 包含 miR29 MicroRNA 的靶位点，并且该蛋白质的表达与 miR29 水平之间存在负相关，表明 miR29 对该基因产物的表达进行调节。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 9 月]

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 MicroRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

CD276 基因产物(4)

mRNA Protein Name
NM_001024736.2 NP_001019907.1 CD276 antigen isoform a precursor
NM_001329628.2 NP_001316557.1 CD276 antigen isoform b precursor
NM_001329629.2 NP_001316558.1 CD276 antigen isoform c
NM_025240.3 NP_079516.1 CD276 antigen isoform b precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18650384 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell activation IDA
IDA: 通过直接分析推断
18650384 GOA
involved in positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
11224528 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
11224528 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD276 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (30 - 127)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (148 - 228)

V-set

V-set: Immunoglobulin V-set domain (247 - 345)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (366 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
蛋白主名 其他名称

CD276 antigen

B7 homolog 3

重组 CD276 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7326 CD276/B7-H3 Protein, Human (435a.a, HEK293, Fc) Q5ZPR3-1 (L29-P463) ≥95%
HY-P7327 CD276/B7-H3 Protein, Human (HEK293, His) Q5ZPR3-2 (L29-P245) ≥95%
HY-P70652 CD276/B7-H3 Protein, Human (433a.a, HEK293, His) Q5ZPR3-1 (L29-T461) ≥95%
HY-P77538 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His) Q5ZPR3-1 (L29-T461) ≥95%
HY-P77578 CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) Q5ZPR3-2 (L29-P245) ≥95%
HY-P78074 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His-Avi) Q5ZPR3-1 (G27-T461) ≥95%
HY-P78391 CD276/B7-H3 Protein, Human (HEK293, His-Avi) Q5ZPR3-1 (G27-T461) ≥95%
HY-P78930 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q5ZPR3-2 (L29-P245) ≥95%
HY-P700448 CD276/B7-H3 Protein, Human (HEK293, Myc-hFc) Q5ZPR3-1 (L29-G245) ≥95%
HY-P700880 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, C-His-Avi) Q5ZPR3-2 (L29-P245) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency

IMD16

Ox40 Deficiency

Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

Combined Immunodeficiency With Impaired Immunity To Hhv-8

Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

Immunodeficiency, Type 16
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Craniopharyngioma

Neoplasm Of Rathke'S Pouch

Adamantinomatous Tumor

Craniopharyngeal Duct Tumor

Dysodontogenic Epithelial Tumor

Rathke'S Pouch Tumor
Autoimmune Peripheral Neuropathy
Central Nervous System Neuroblastoma
Rhabdomyosarcoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99157 Omburtamab Inhibitor 98.27% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02220 CD276 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99740 Mirzotamab Inhibitor 99.45% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CD276 RGD RGD:727815
Canis familiaris CD276 VGNC VGNC:38943
Felis catus CD276 VGNC VGNC:60603
Bos taurus CD276 VGNC VGNC:27020
Mus musculus CD276 MGD MGI:2183926
Macaca mulatta CD276 VGNC VGNC:70826
Macaca fascicularis CD276 NCBI NCBI:102131295
Others CD276 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z