2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Biotinylated Proteins
  4. Stimulatory Immune Checkpoint Molecules T Cell CD Proteins B Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Dendritic Cell CD Proteins
  5. CD28
  6. CD28 蛋白, Mouse (Biotinylated , HEK293, His)

CD28 蛋白, Mouse (Biotinylated , HEK293, His)

目录号: HY-P74311
产品使用指南

CD28 蛋白是 T 细胞激活的重要调节因子，可促进细胞增殖、细胞因子产生和 T 细胞存活。与 TCR/CD3 连接和 CD40L 共刺激结合时，它可增强 IL4 和 IL10 的产生。CD28 蛋白以二硫键连接的同二聚体形式存在，并与 DUSP14、CD80/B7-1、CD86/B7-2/B70 和 GRB2 相互作用（通过相似性）。CD28 蛋白, Mouse (Biotinylated, HEK293, His) 是重组的 CD28 蛋白，由 HEK293 表达，带有 C-His 标签。CD28 蛋白, Mouse (Biotinylated, HEK293, His) 全长 130 个氨基酸，分子量为 32-35 kDa。

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SPR 检测服务   重组蛋白定制服务

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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3.  试用装只面向终端客户。

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100 μg   询价  

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描述

CD28 Protein, a crucial regulator of T-cell activation, promotes cell proliferation, cytokine production, and T-cell survival. It enhances IL4 and IL10 production when combined with TCR/CD3 ligation and CD40L costimulation. CD28 Protein exists as a disulfide-linked homodimer and interacts with DUSP14, CD80/B7-1, CD86/B7-2/B70, and GRB2 (By similarity). CD28 Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived CD28 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD28 Protein, Mouse (Biotinylated, HEK293, His) is 130 a.a., with molecular weight of 32-35 kDa.
研究背景

CD28 蛋白是 T 细胞激活的关键参与者，参与诱导细胞增殖、细胞因子产生和促进 T 细胞存活。与 TCR/CD3 连接和 CD40L 共刺激相结合时，它可增强 T 细胞中 IL4 和 IL10 的产生。CD28 蛋白通过二硫键以同二聚体形式存在，并与 DUSP14 相互作用。它与 CD80/B7-1 和 CD86/B7-2/B70 结合，并且还与 GRB2 相互作用（通过相似性）。
种属

Mouse
表达系统

HEK293
标签

C-His
蛋白编号

P31041 (N20-K149)
基因 ID
蛋白结构
N-term
CD28 (N20-K149)
Accession # P31041
His
C-term
同用名
CD28; T-cell-specific surface glycoprotein CD28; Tp44
分子量

32-35 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

CD28 Protein, Mouse (Biotinylated , HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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