2. Gene
  3. Cd28 - CD28 antigen Gene

Cd28 - CD28 antigen Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CD28 抗原

种属: Mus musculus

基因 ID: 12487 | 基因类型: protein coding

关于 Cd28

Chromosome 1: 60,755,959-60,812,518 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue.

功能概要

该基因编码的蛋白可启动蛋白激酶结合活性。作用于多个过程的上游或内部，包括免疫反应的正向调节；细胞内信号转导的正向调节；和淋巴细胞活化的调节。位于质膜和免疫突触的外侧。该基因的人类直系同源物与多发性硬化症和 1 型糖尿病有关。与人 CD28（CD28 分子）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd28 基因产物(2)

mRNA Protein Name
NM_007642.4 NP_031668.3 T-cell-specific surface glycoprotein CD28 precursor
NM_007642.4 NP_031668.3 T-cell-specific surface glycoprotein CD28 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
21245484 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
8125140 MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
9368605 MGI
acts upstream of or within T cell costimulation IDA
IDA: 通过直接分析推断
8125140 MGI
acts upstream of or within T cell costimulation IGI
IGI: 通过遗传相互作用推断
23793062 MGI
acts upstream of or within T cell costimulation IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
12925852 MGI
acts upstream of T cell proliferation IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
23793062 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
10429671 MGI
acts upstream of interleukin-2 production IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
10429671 MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
23589618 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
8125140 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
9368605 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
12867038 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of or within positive regulation of inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
10791997 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes IMP
IMP: 通过突变表型推断
7688139 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
23589618 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16809611 MGI
acts upstream of or within regulation of regulatory T cell differentiation IGI
IGI: 通过遗传相互作用推断
21245484 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16809611 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7790813 MGI
located in external side of plasma membrane IMP
IMP: 通过突变表型推断
7688139 MGI
located in immunological synapse IDA
IDA: 通过直接分析推断
23793062 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cd28 蛋白结构

Ig

Ig: cl11960 (21 - 137)

Ig

Ig: cd00096 (36 - 40)

Ig

Ig: cd00096 (52 - 56)

Ig

Ig: cd00096 (95 - 99)

Ig

Ig: cd00096 (109 - 114)

Ig

Ig: cd00096 (127 - 131)

  • 0
  • 100
  • 200
  • 218 a.a.
蛋白主名 其他名称

T-cell-specific surface glycoprotein CD28

重组 Cd28 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70614 CD28 Protein, Mouse (HEK293, Fc-His) P31041 (N20-K149) ≥95%
HY-P74311 CD28 Protein, Mouse (Biotinylated , HEK293, His) P31041 (N20-K149) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P1698 Reltecimod Antagonist 99.88% Phase 3
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P99961 Tifcemalimab Inhibitor 95.00% Phase 3
HY-P99293 Galiximab Inhibitor 99.23% Phase 3
HY-P99302 Lulizumab Inhibitor ≥95.0% Phase 2
HY-P99420 Acazicolcept Antagonist 99.27% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102090 B7/CD28 interaction inhibitor 1 99.47% 否
HY-P1698B Reltecimod TFA Chemical 99.78% 否
HY-100891 CD80-IN-3 98.08% 否
HY-162810 ICOS-IN-1 / 否
HY-N10446 Maydispenoid B / 否
HY-19486 UR-1505 Inhibitor / 否
HY-N10445 Maydispenoid A / 否
抗体抑制剂 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P9975 Theralizumab Agonist 99.46% 否
HY-P99123 Anti-Mouse CD28 Antibody (37.51) ≥95.0% 否
HY-P990752 Nezastomig / 否
HY-P990938 Pegrizeprument / 否
HY-P991038 Zadoprubart / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd28 NCBI NCBI:940
Canis familiaris Cd28 NCBI NCBI:403646
Macaca fascicularis Cd28 NCBI NCBI:102146670
Rattus norvegicus Cd28 NCBI NCBI:25660
Macaca mulatta Cd28 NCBI NCBI:705313
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