2. Anti-infection Immunology/Inflammation
  3. Bacterial CD28
  4. Reltecimod

Reltecimod  (Synonyms: AB-103)

目录号: HY-P1698 纯度: 99.88%
COA 产品使用指南

摩尔计算器

Reltecimod (AB-103) 是一种 T 细胞特异性表面糖蛋白 CD28 (TP44) 拮抗剂。Reltecimod对不同的细菌感染、细菌外毒素和内毒素以及电离辐射都有良好的抗性作用。Reltecimod 通过靶向和减弱关键的 CD28/B7-2 共刺激通路来调节炎症反应，而不抑制它。Reltecimod 可用于研究坏死性软组织感染 (NSTIs)。

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Custom Peptide Synthesis

Reltecimod Chemical Structure

Reltecimod Chemical Structure

CAS No. : 1447799-33-8

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规格 价格 是否有货 数量
5 mg ￥406
In-stock
10 mg ￥650
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Reltecimod:

Reltecimod 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs)[1][2].

IC50 & Target

TP44, Bacteria[1][2]
体内研究
(In Vivo)

Reltecimod (1.25-5 mg/kg; i.v.) 可提高感染不同细菌的小鼠的存活率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration with E. coli 018:K1)[2]
Dosage: 1.25 or 5 mg/kg
Administration: i.v.; single dosage; at 4 h post infection
Result: Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration with Streptococcus pyogenes)[2]
Dosage: 2.5 or 5 mg/kg
Administration: i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection
Result: Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2]
Dosage: 1.25, 2.5, or 5 mg/kg
Administration: i.v.; single dosage
Result: Increased day 7 survival by up to 100%.
Clinical Trial
分子量

1037.19

Formula

C46H72N10O15S
CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

ASPMLVAYDA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (96.41 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9641 mL 4.8207 mL 9.6414 mL
5 mM 0.1928 mL 0.9641 mL 1.9283 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Reltecimod 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9641 mL 4.8207 mL 9.6414 mL 24.1036 mL
5 mM 0.1928 mL 0.9641 mL 1.9283 mL 4.8207 mL
10 mM 0.0964 mL 0.4821 mL 0.9641 mL 2.4104 mL
15 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6069 mL
20 mM 0.0482 mL 0.2410 mL 0.4821 mL 1.2052 mL
25 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9641 mL
30 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8035 mL
40 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6026 mL
50 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
60 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
80 mM 0.0121 mL 0.0603 mL 0.1205 mL 0.3013 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reltecimod1447799-33-8AB-103AB103AB 103BacterialCD28NSTIsTP44T cellE. coliStreptococcus pyogenesCecal ligation and punctureCLPInhibitorinhibitorinhibit

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