1. 重组蛋白
  2. CD Antigens
  3. Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins
  4. CLM-7/CD300b
  5. CD300LB 蛋白, Human (HEK293, hFc)

CD300LB 蛋白, Human (HEK293, hFc)

目录号: HY-P72774
产品使用指南

CD300LB 蛋白是一种激活性免疫受体,通过与带有 ITAM 的接头 TYROBP 相互作用并独立招募 GRB2 来参与免疫调节。与 TYROBP 的相互作用增强细胞表面表达和激活特性。在 FYN 存在的情况下,CD300LB 还与 GRB2 相互作用,展示了其对免疫信号通路的多方面贡献。CD300LB 蛋白, Human (HEK293, hFc) 是重组的 CD300LB 蛋白,由 HEK293 表达,带有 C-hFc 标签。

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描述

CD300LB Protein, an activating immune receptor, engages in immune modulation by interacting with the ITAM-bearing adapter TYROBP and recruiting GRB2 independently. The interaction with TYROBP enhances cell surface expression and activation properties. In the presence of FYN, CD300LB also interacts with GRB2, showcasing its multifaceted contribution to immune signaling pathways. CD300LB Protein, Human (HEK293, hFc) is the recombinant human-derived CD300LB protein, expressed by HEK293 , with C-hFc labeled tag.

研究背景

CD300LB 蛋白作为一种激活性免疫受体发挥作用,通过与带有 ITAM 的接头 TYROBP 相互作用并独立地招募 GRB2 来发挥其免疫调节作用。它与 TYROBP 的相互作用不仅增强细胞表面表达,还增强激活特性。在 FYN 存在的情况下,CD300LB 进一步与 GRB2 相互作用,揭示了该蛋白促进免疫信号通路的多方面机制。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

AAH28091.1 (I55-H187)

基因 ID
蛋白结构
N-term
CD300LB (I55-H187)
Accession # AAH28091.1
hFc
C-term
同用名
CD300b; CLM-7; CLM-7; CMRF35-A2; IREM-3; IREM3; TREM-5; TREM5; CD300LB
氨基酸序列

IQGPESVRAPEQGSLTVQCHYKQGWETYIKWWCRGVRWDTCKILIETRGSEQGEKSDRVSIKDNQKDRTFTVTMEGLRRDDADVYWCGIERRGPDLGTQVKVIVDPEGAASTTASSPTNSNMAVFIGSHKRNH

分子量

50-60 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD300LB Protein, Human (HEK293, hFc)
目录号:
HY-P72774
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