CD38 蛋白, Cynomolgus (HEK293, His)

The CD38 protein plays multifaceted roles in cell signaling and is critical for the synthesis of cyclic ADP-ribose (cADPR) as a possible second messenger in glucose-induced insulin secretion. CD38 also promotes calcium mobilization through the synthesis of niacin adenine dinucleotide phosphate (NAADP+) and exhibits cADPR hydrolase activity. CD38 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD38 Protein, Cynomolgus (HEK293, His) is 258 a.a., with molecular weight of 38-50 kDa.

CD38 蛋白在细胞信号传导中发挥多方面的作用，在环状 ADP-核糖 (cADPR) 的合成中发挥关键作用，cADPR 被认为是可能对葡萄糖诱导的胰岛素分泌至关重要的第二信使。此外，CD38 通过合成源自 2'-磷酸-cADPR 和烟酸以及 NADP(+) 和烟酸的烟酸-腺嘌呤二核苷酸磷酸盐 NAADP(+) 来促进钙动员。除了其合成功能外，CD38 还表现出 cADPR 水解酶活性，表明其参与这些信号分子的动态调节。这种复杂的活动序列强调了 CD38 在介导关键细胞反应中发挥的核心作用，特别是在胰岛素分泌和钙动员的背景下。

Cynomolgus

HEK293

C-6*His

Q5VAN0 (L44-I301)

102126394  [NCBI]

LPRWRQQWSGSGTTSRFPETVLARCVKYTEVHPEMRHVDCQSVWDAFKGAFISKYPCNITEEDYQPLVKLGTQTVPCNKTLLWSRIKDLAHQFTQVQRDMFTLEDMLLGYLADDLTWCGEFNTFEINYQSCPDWRKDCSNNPVSVFWKTVSRRFAETACGVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQALEAWVIHGGREDSRDLCQDPTIKELESIISKRNIRFFCKNIYRPDKFLQCVKNPEDSSCLSGI

38-50 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.