CD42a/GP9 蛋白, Human (HEK293, Fc)

CD42a/GP9 protein, forming the GPIb-V-IX complex, acts as the von Willebrand factor (vWF) receptor, facilitating vWF-dependent platelet adhesion to blood vessels—a crucial step in arterial hemostasis. The GP-IX component contributes to the membrane insertion and orientation of GP-Ib, forming a non-covalent linkage with the GP-Ib heterodimer composed of two GP-Ib beta subunits and one GP-Ib alpha subunit. CD42a/GP9 Protein, Human (HEK293, Fc) is the recombinant human-derived CD42a/GP9 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD42a/GP9 Protein, Human (HEK293, Fc) is 131 a.a., with molecular weight of 48-52 kDa.

CD42a/GP9 蛋白，也称为 GPIb-V-IX 复合物，作为冯维勒布兰德因子 (vWF) 受体发挥着关键作用，促进 vWF 依赖性血小板粘附到血管。这种相互作用是止血的关键初始步骤，特别是在应对动脉循环损伤时。GP-IX 位于 GPIb-V-IX 复合体中，参与 GP-Ib 的膜插入和定向。值得注意的是，两个 GP-Ib β 亚基通过二硫键连接至一个 GP-Ib α 亚基，并且 GP-IX 组分与 GP-Ib 异二聚体形成非共价连接。

Human

HEK293

C-hFc

P14770 (T17-G147)

2815  [NCBI]

48-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of 20 mM Tris, 250 mM NaCl, pH 8.5. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.