GP9 - glycoprotein IX platelet Gene

中文名称：糖蛋白 IX 血小板

种属: Homo sapiens

同用名: GPIX; CD42a

基因 ID: 2815 | 基因类型: protein coding

关于 GP9

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:129,054,845-129,062,406 (from NCBI)

This gene has 1 transcript (splice variant), 160 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in bone marrow (RPKM 1.0), spleen (RPKM 0.7) and 4 other tissues.

功能概要

该基因编码一种在人类血小板表面发现的小膜糖蛋白。它与糖蛋白 Ib 形成一对一的非共价复合物，糖蛋白 Ib 是一种血小板表面膜糖蛋白复合物，可作为血管性血友病因子的受体。完整的受体复合物包括 alpha 和 beta 亚基与该基因编码的蛋白质和血小板糖蛋白 V 的非共价结合。该基因的缺陷是 Bernard-Soulier 综合征 (也称为巨血小板病) 的原因。这些患者的血小板异常大，有临床出血倾向。[RefSeq 提供，2008 年 10 月]

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008]

GP9 基因产物(1)

mRNA	Protein	Name
NM_000174.5	NP_000165.1	platelet glycoprotein IX precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	1730602	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in blood coagulation, intrinsic pathway	IPI IPI: 通过物理相互作用推断	10501658	GOA
involved in positive regulation of platelet activation	IDA IDA: 通过直接分析推断	1939645	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: 通过直接分析推断	1939645	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of glycoprotein Ib-IX-V complex	IPI IPI: 通过物理相互作用推断	1730602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GP9 蛋白结构

LRRNT

LRR_8

0
100
177 a.a.

蛋白主名

其他名称

platelet glycoprotein IX

glycoprotein 9

GP9 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GP9	P14770	GP5	Homo sapiens	P40197	Anti Bait CoIP	1730602
种属内	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
种属内	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
种属内	GP9	P14770	HOXA1	Homo sapiens	P49639	Y2H Array	31515488
种属内	GP9	P14770	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GP9 蛋白

目录号	产品名	蛋白编号	纯度
HY-P77953	CD42a/GP9 Protein, Human (HEK293, Fc)	P14770 (T17-G147)	≥95%

关联疾病

疾病名称

别名

Bernard-Soulier Syndrome

Giant Platelet Syndrome	BSS
Von Willebrand Factor Receptor Deficiency	Bdplt1
Platelet Glycoprotein Ib Deficiency	Bernard-Soulier Syndrome, Type A1
Bernard-Soulier Syndrome, Type B	Bernard Soulier Syndrome
Deficiency Of Platelet Glycoprotein 1b	Hemorrhagiparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type C	Bleeding Disorder, Platelet-Type, 1
Glycoprotein Ib, Platelet, Deficiency Of	Giant Platelet Disorder, Isolated
Giant Platelet Disease	Macrothrombocytopenia, Familial Bernard-Soulier Type
Bernard-Soulier Syndrome, Type C	Bernard - Soulier Thrombopathy
Hemorrhagic Dystrophic Thrombocytopenia	Thrombopathy, Bernard-Soulier
Platelet Glycoprotein 1b, Deficiency Of	Hemorrhagioparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type A1	Bernard-Soulier Syndrome Type B
Bleeding Disorder Platelet-Type 1	Gpd
Macrothrombocytopenia, Familial, Bernard-Soulier Type

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency	GPS
Bdplt4	Bleeding Disorder, Platelet-Type, 4
Grey Platelet Syndrome	Platelet-Type Bleeding Disorder 4
Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins	Deficient Alpha Granule Syndrome
Platelet Alpha Granule Deficiency	Platelet Granule Defect
Alpha Storage Pool Deficiency	Bleeding Disorder Platelet-Type 4

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Pseudo-Von Willebrand Disease

Bdplt3	Von Willebrand Disease, Platelet-Type
VWDP	Platelet-Type Bleeding Disorder 3
Platelet Type-Von Willebrand Disease	Pt-Vwd
Von Willebrand Disease Platelet-Type	Von Willebrand Disease, Platelet Type
Pseudo Von Willebrand Disease	Bleeding Disorder, Platelet-Type, 3
Pseudo-Von Willebrand Disease Type 2b	Bleeding Disorder Platelet-Type 3
Pseudo-Vwd

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Thrombasthenia

Bardet-Biedl Syndrome 5

BBS5	Bardet-Biedl Syndrome, Type 5

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Acrokeratoderma, Hereditary Papulotranslucent

Hereditary Papulotranslucent Acrokeratoderma

Jacobsen Syndrome

Chromosome 11q Deletion Syndrome	Partial 11q Monosomy Syndrome
Jacobsen Distal 11q Deletion Syndrome	JBS
11q Partial Monosomy Syndrome	Chromosome 11q Deletion
11q Deletion	11q Monosomy
Deletion 11q	Monosomy 11q
Partial Monosomy 11q	11q Deletion Disorder
11q Deletion Syndrome	11q Terminal Deletion Disorder
11q- Deletion Syndrome	11q23 Deletion Disorder
Jacobsen Thrombocytopenia	11q Terminal Deletion Syndrome
Del(11)(Q23.3)	Del(11)(Qter)
Distal Deletion 11q	Distal Monosomy 11q
Monosomy 11qter	Telomeric Deletion 11q
Paris-Trousseau Thrombocytopenia

Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia	Thrombasthenia Of Glanzmann And Naegeli
Glanzmann'S Thrombasthenia	Bdplt2
Platelet Glycoprotein Iib-Iiia Deficiency	Deficiency Of Platelet Fibrinogen Receptor
GT1	Gt
Platelet Fibrinogen Receptor Deficiency	Glycoprotein Complex Iib-Iiia Deficiency
Deficiency Of Glycoprotein Complex Iib-Iiia	Glycoprotein Iib/Iiia Defect
Glanzmann Thrombasthenia, Type A	Thrombasthenia
Bleeding Disorder, Platelet-Type, 2	Gp Iib-Iiia Complex Deficiency
Deficiency Of Gp Iib-Iiia Complex	Platelet-Type Bleeding Disorder 2
Thrombocytasthenia	Deficiency Of Gp 2b 3a Complex
Diacyclothrombopathia 2b 3a	Glanzmann Thrombasthenia Type A
Platelet Fibrinogen Receptor, Deficiency Of	Platelet Glycoprotein 2b 3a Deficiency
Glanzmann Disease	Glanzmann-Naegeli Disorder
Hereditary Hemorrhagic Thrombasthenia	Hereditary Thrombasthenia
Bleeding Disorder Platelet-Type 2

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia	Autoimmune Thrombocytopenia
Immune Thrombocytopenic Purpura	Itp
Auto-Immune Thrombocytopenia	Thrombocytopenia Due To Immune Destruction
Autoimmune Thrombocytopenic Purpura	Idiopathic Thrombocytopenic Purpura
Werlhof Disease

Myh-9 Related Disease

Myh9-Related Disease	Myh9-Rd
Myh9-Related Disorder	Myh9-Related Syndrome
Myh9-Related Syndromic Thrombocytopenia	Sebastian Syndrome

Von Willebrand'S Disease

Von Willebrand Disease	Von Willebrand Disorder
Vascular Pseudohemophilia	Hereditary Von Willebrand Disease
Vwd	Vascular Hemophilia
Von Willebrand'S-Jurgens' Disease	Von Willebrand-Jrgens Disease
Von Willebrand Factor Deficiency	Von Willebrand Factor, Deficiency
Angiohemophilia	Von Willebrand'S Factor Deficiency
Von Willebrand Diseases	Factor Viii Deficiency With Vascular Defect
Vascular Haemophilia	Willebrand Jurgen Thrombopathy
Pseudohaemophilia	Minot-Von Willebrand-Jurgen Disease
Angiohaemophilia	Angiohaemophilia A
Angiohaemophilia B

Blood Coagulation Disease

Blood Coagulation Disorders	Coagulation Protein Disease
Inherited Blood Coagulation Disease	Postpartum Coagulation Defect
Postpartum Coagulation Defect With Delivery	Coagulation Protein Disorders
Puerperal Coagulopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05612	GP9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GP9	VGNC	VGNC:29507
Rattus norvegicus	GP9	RGD	RGD:1561601
Mus musculus	GP9	MGD	MGI:1860137
Felis catus	GP9	VGNC	VGNC:67399
Canis familiaris	GP9	VGNC	VGNC:41357
Macaca mulatta	GP9	VGNC	VGNC:73115
Macaca fascicularis	GP9	NCBI	NCBI:102137361
Others	GP9	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GP9 - glycoprotein IX platelet Gene

关于 GP9

功能概要

GP9 基因产物(1)

GP9 蛋白结构

GP9 蛋白互作信息

重组 GP9 蛋白

关联疾病

直系同源

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GP9 - glycoprotein IX platelet Gene

关于 GP9

功能概要

GP9 基因产物(1)

GP9 蛋白结构

GP9 蛋白互作信息

重组 GP9 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z