GP5 - glycoprotein V platelet Gene

中文名称：糖蛋白 V 血小板

种属: Homo sapiens

同用名: GPV; CD42d

基因 ID: 2814 | 基因类型: protein coding

关于 GP5

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,394,821-194,399,266 (from NCBI)

This gene has 2 transcripts (splice variants), 157 orthologues and 25 paralogues. Low expression observed in reference dataset.

功能概要

人血小板糖蛋白 V (GP5) 是表面糖蛋白 Ib-V-IX 系统的一部分，构成血管性血友病因子 (VWF；MIM 613160) 的受体，并介导血小板与动脉循环中受损血管表面的粘附，止血中的关键起始事件。受体的主要部分是由 2 条多肽链组成的异二聚体，一条 α 链 (GP1BA；MIM 606672) 和一条 β 链 (GP1BB；MIM 138720) ，它们通过二硫键连接。完整的受体复合物包括 α 和 β 亚基与血小板糖蛋白 IX (GP9；MIM 173515) 和 GP5 的非共价结合。 GP1BA、GP1BB 和 GP9 的突变已被证明会导致 Bernard-Soulier 综合征 (MIM 231200) ，这是一种出血性疾病 (Lopez 等人的评论，1998 [PubMed 9616133]) 。[OMIM 提供，2010 年 11 月]

Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for von Willebrand factor (VWF; MIM 613160) and mediate the adhesion of platelets to injured vascular surfaces in the arterial circulation, a critical initiating event in hemostasis. The main portion of the receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide bonds. The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX (GP9; MIM 173515) and GP5. Mutations in GP1BA, GP1BB, and GP9 have been shown to cause Bernard-Soulier syndrome (MIM 231200), a bleeding disorder (review by Lopez et al., 1998 [PubMed 9616133]).[supplied by OMIM, Nov 2010]

GP5 基因产物(1)

mRNA	Protein	Name
NM_004488.2	NP_004479.1	platelet glycoprotein V precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	1730602	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in blood coagulation, intrinsic pathway	IPI IPI: 通过物理相互作用推断	10501658	GOA
involved in positive regulation of platelet activation	IDA IDA: 通过直接分析推断	1939645	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: 通过直接分析推断	1939645	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of glycoprotein Ib-IX-V complex	IPI IPI: 通过物理相互作用推断	1730602	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GP5 蛋白结构

LRR_8

LRR_1

LRR_8

0
100
200
300
400
500
560 a.a.

蛋白主名

其他名称

platelet glycoprotein V

glycoprotein 5

GP5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GP5	P40197	GP9	Homo sapiens	P14770	Anti Bait CoIP	1730602

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Bernard-Soulier Syndrome

Giant Platelet Syndrome	BSS
Von Willebrand Factor Receptor Deficiency	Bdplt1
Platelet Glycoprotein Ib Deficiency	Bernard-Soulier Syndrome, Type A1
Bernard-Soulier Syndrome, Type B	Bernard Soulier Syndrome
Deficiency Of Platelet Glycoprotein 1b	Hemorrhagiparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type C	Bleeding Disorder, Platelet-Type, 1
Glycoprotein Ib, Platelet, Deficiency Of	Giant Platelet Disorder, Isolated
Giant Platelet Disease	Macrothrombocytopenia, Familial Bernard-Soulier Type
Bernard-Soulier Syndrome, Type C	Bernard - Soulier Thrombopathy
Hemorrhagic Dystrophic Thrombocytopenia	Thrombopathy, Bernard-Soulier
Platelet Glycoprotein 1b, Deficiency Of	Hemorrhagioparous Thrombocytic Dystrophy
Bernard-Soulier Syndrome Type A1	Bernard-Soulier Syndrome Type B
Bleeding Disorder Platelet-Type 1	Gpd
Macrothrombocytopenia, Familial, Bernard-Soulier Type

Penile Cancer

Penis Carcinoma	Carcinoma Of Penis
Penile Neoplasm	Penile Carcinoma
Penile Neoplasms	Malignant Neoplasm Of Penis
Ca Penis	Malignant Neoplasm Of Body Of Penis
Malignant Penile Tumor	Penile Ca

Ureter Inverted Papilloma

Ureteral Inverted Papilloma

Ureter Urothelial Papilloma

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia	Autoimmune Thrombocytopenia
Immune Thrombocytopenic Purpura	Itp
Auto-Immune Thrombocytopenia	Thrombocytopenia Due To Immune Destruction
Autoimmune Thrombocytopenic Purpura	Idiopathic Thrombocytopenic Purpura
Werlhof Disease

Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency	GPS
Bdplt4	Bleeding Disorder, Platelet-Type, 4
Grey Platelet Syndrome	Platelet-Type Bleeding Disorder 4
Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins	Deficient Alpha Granule Syndrome
Platelet Alpha Granule Deficiency	Platelet Granule Defect
Alpha Storage Pool Deficiency	Bleeding Disorder Platelet-Type 4

Uterus Carcinoma In Situ

Cervical Adenosarcoma

Cervical Muellerian Adenosarcoma

Cervical Mullerian Adenosarcoma

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix	Carcinoma In Situ Of Uterine Cervix
Cervical Intraepithelial Neoplasia	Carcinoma Of Cervix Stage 0
Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia	Cervix Ca In Situ
Cin Iii	Cin Iii - Carcinoma In Situ Of Cervix
Cin Iii - Severe Dyskaryosis	Severe Dysplasia Of Cervix
Severe Dysplasia Of The Cervix Uteri	Squamous Intraepithelial Neoplasia, Grade Iii
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Penis Basal Cell Carcinoma

Basal Cell Carcinoma Of The Penis

Inverted Follicular Keratosis

Inverted Folicular Keratosis

Seborrheic Keratosis

Penile Benign Neoplasm

Neoplasm Of Penis	Penile Tumor
Cancer Of Penis	Carcinoma Of Penis
Malignant Neoplasm Of Penis, Unspecified	Malignant Neoplasm Of Penis, Part Unspecified
Malignant Tumour Of Penis	Penile Cancer
Primary Malignant Neoplasm Of Penis	Malignant Neoplasm Of Skin Of Penis Nos

Focal Epithelial Hyperplasia

Heck'S Disease	Heck Disease
Multifocal Epithelial Hyperplasia

Vulva Cancer

Vulvar Carcinoma	Malignant Neoplasm Of Vulva
Vulva Carcinoma	Carcinoma Of Vulva
Vulvar Cancer	Vulval Cancer
Vulvar Neoplasms	Ca Vulva
Malignant Tumor Of Vulva	Malignant Vulvar Tumor
Neoplasm Of Vulva	Vulval Neoplasm
Vulvar Neoplasm	Vulvar Tumor
Cancer Of Vulva	Malignant Tumour Of Vulva

Anogenital Venereal Wart

Genital Warts	Condylomata Acuminata
Anogenital Warts	Condyloma Acuminatum
Anogenital Human Papilloma Virus Infectious Disease	Genital Wart Virus Infectious Disease
Venereal Wart	Venereal Warts
Verrucae Anogenitales	Verrucae Genitales

Anus Cancer

Anal Cancer	Anal Carcinoma
Malignant Anal Tumor	Cancer Of The Anus
Malignant Neoplasm Of Anus	Anus Neoplasms

Chronic Cervicitis

Middle Ear Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Middle Ear

Epidermoid Carcinoma Of The Middle Ear

Vaginal Cancer

Malignant Neoplasm Of Vagina	Vaginal Neoplasms
Malignant Tumor Of Vagina	Malignant Vaginal Tumor
Neoplasm Of Vagina	Vagina Neoplasm
Vaginal Tumor	Vaginal Carcinoma
Vaginal Malignant Epithelial Tumor	Vaginal Neoplasm
Malignant Vaginal Neoplasm	Vagina Carcinoma
Vaginal Neoplasia	Cancer Of Vagina
Malignant Tumour Of Vagina	Carcinoma Of Vagina
Primary Malignant Neoplasm Of Vagina	Vagina Wall Cancer
Vaginal Wall Cancer

Cervical Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Cervix Uteri

Anus Disease

Anal Fissure	Ulcer Of Anus
Anus Diseases	Anal Disease
Anal Fissure And Fistula	Anal Ulcer
Fissure In Ano	Nontraumatic Tear Of Anus
Solitary Anal Ulcer	Abnormality Of The Anus
Anal Disorders	Ulcer Of Anus And Rectum
Solitary Ulcer Of Anus	Stercoral Ulcer Of Anus

Middle Ear Carcinoma

Carcinoma Of Middle Ear

Carcinoma Of The Middle Ear

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Verrucous Carcinoma

Verrucous Squamous Carcinoma	Verrucous Squamous Cell Carcinoma
Warty Carcinoma	Carcinoma Verrucous
Carcinoma, Verrucous

Cervicitis

Uterine Cervicitis

Inflammation Of Cervix

Squamous Cell Papilloma

Papilloma	Epidermoid Papilloma
Papilloma, Squamous Cell

Vulva Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Vulva	Vulvar Squamous Cell Carcinoma
Vulvar Epidermoid Carcinoma	Squamous Cell Carcinoma Of The Vulva

Cervical Carcinosarcoma

Cervical Malignant Mixed Mesodermal Mullerian Tumor	Cervical Malignant Mixed Mullerian Tumor
Cervical Mixed Epithelial And Mesenchymal Neoplasm

Comedo Carcinoma

Comedocarcinoma

High Grade Ductal Breast Carcinoma In Situ

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Oropharynx Cancer

Oropharyngeal Cancer	Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx	Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx	Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult	Cancer Of The Oropharynx

Penile Disease

Penile Diseases

Adenocarcinoma In Situ

Male Reproductive Organ Benign Neoplasm

Hemophilia B

Christmas Disease	Factor Ix Deficiency
F9 Deficiency	HEMB
Plasma Thromboplastin Component Deficiency	Congenital Factor Ix Deficiency
Mild Hemophilia B	Severe Hemophilia B
Congenital Factor Ix Disorder	Deficiency, Functional Factor Ix
Hem B	Mild Congenital F9 Deficiency
Mild Congenital Factor Ix Deficiency	Moderate Hemophilia B
Moderate Congenital F9 Deficiency	Moderate Congenital Factor Ix Deficiency
Severe Congenital F9 Deficiency	Severe Congenital Factor Ix Deficiency
Bleeding Disorder In Hemophilia B Carriers	Congenital F9 Deficiency
Recessive X-Linked Hemophilia B

Human Papillomavirus Infectious Disease

Hpv	Papillomavirus Infections
Human Papilloma Virus Infection

Vulvar Disease

Vulvar Diseases

Vulvar Disorders

Common Wart

Verruca Vulgaris	Viral Warts Nos
Filiform Warts	Digitate Warts

Rectal Disease

Rectal Diseases

Rectal Disorders

Phimosis

Tight Foreskin	Tight Frenulum
Congenital Phimosis

Cervix Carcinoma

Cancer Of Cervix	Carcinoma Of Cervix
Carcinoma Cervix Uteri	Carcinoma Of The Cervix Uteri

直系同源

种属	基因名	来源	基因 ID
Mus musculus	GP5	MGD	MGI:1096363
Bos taurus	GP5	VGNC	VGNC:29506
Rattus norvegicus	GP5	RGD	RGD:2724
Macaca mulatta	GP5	VGNC	VGNC:110362
Felis catus	GP5	VGNC	VGNC:102750
Macaca fascicularis	GP5	NCBI	NCBI:102143729
Others	GP5	NCBI

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营业执照（三证合一）

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-110382	Cyclic-di-GMP disodium	Activator	99.23%	否
HY-107780B	Cyclic-di-GMP diammonium	Activator	99.07%	否
HY-107780	Cyclic-di-GMP	Activator	98.18%	否
HY-107780A	Cyclic-di-GMP sodium	Activator	/	否
HY-RS05610	GP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

GP5 - glycoprotein V platelet Gene

关于 GP5

功能概要

GP5 基因产物(1)

GP5 蛋白结构

GP5 蛋白互作信息

关联疾病

直系同源

热门区域

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GP5 - glycoprotein V platelet Gene

关于 GP5

功能概要

GP5 基因产物(1)

GP5 蛋白结构

GP5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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