CD42c/GP1BB 蛋白, Human (HEK293, His)

CD42c/GP1BB protein, present on platelets, interacts with von Willebrand factor to form platelet plugs. It forms a heterodimer with GP1B beta subunits and associates with GP-IX, facilitating platelet adhesion and initiating thrombus formation. CD42c also interacts with TRAF4, potentially regulating cellular signaling pathways. CD42c/GP1BB Protein, Human (HEK293, His) is the recombinant human-derived CD42c/GP1BB protein, expressed by HEK293 , with C-His labeled tag.

CD42c，也称为 GP1BB，是血小板上的一种表面膜蛋白，通过与血管性血友病因子相互作用，对血小板栓塞的形成至关重要，血管性血友病因子预先结合在内皮下。GP1BB 蛋白与两个二硫键连接的 GP1B β 亚基形成异二聚体，并与 GP-IX 非共价结合。GP1BB、GP1B α 和 GP-IX 的这种复杂复合物在介导血小板粘附和启动血栓形成过程中发挥着关键作用。此外，CD42c 已被确定与 TRAF4 相互作用，表明在细胞信号传导途径中具有潜在的调节作用。

Human

HEK293

C-His

P13224-1/NP_000398.1 (P27-C147)

2812  [NCBI]

MGSGPRGALSLLLLLLAPPSRPAAGCPAPCSCAGTLVDCGRRGLTWASLPTAFPVDTTELVLTGNNLTALPPGLLDALPALRTAHLGANPWRCDCRLVPLRAWLAGRPERAPYRDLRCVAPPALRGRLLPYLAEDELRAACAPGPLC

Approximately 20 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4 or PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.