CD42c/GP1BB 蛋白, Rat (HEK293, Fc)

The CD42c protein is a platelet surface membrane protein that actively assembles plugs by binding to von Willebrand factor (vWF) in the subendothelium. The GP-Ib heterodimer is formed from the disulfide-linked GP-Ib β subunit and one GP-Ib α subunit, which constitute this protein complex. CD42c/GP1BB Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD42c protein, expressed by HEK293 , with C-hFc labeled tag.

CD42c 是血小板上的一种表面膜蛋白，通过与预先结合在内皮下的血管性血友病因子 (vWF) 结合，积极促进血小板栓塞的组装。该蛋白质复合物包含两个通过二硫键连接到一个 GP-Ib α 亚基的 GP-Ib β 亚基，形成 GP-Ib 异二聚体。此外，GP-IX 通过非共价连接与 GP-Ib 异二聚体错综复杂地结合，增强了该血小板表面受体的结构完整性和功能性。在分子相互作用中，CD42c 与肿瘤坏死因子受体相关因子 4 (TRAF4) 的关联相似，有助于调控血小板功能的调节网络。

Rat

HEK293

C-hFc

Q9JJM7 (P27-C147)

116727  [NCBI]

PAPCRCSETRVDCGRRGLTWASLPAAFPPDTTELVLTDNNLTALPPGLLDTLPALRRVHLGANPWRCDCRLLPLRAWLAGRPEREFYRDLRCVAPLALRGRLLPYVAEDELRAACAPGLLC

Approximately 45-55 kDa due to the glycosylation.

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.