CD55/DAF 蛋白, Mouse (HEK293, His)

The CD55/DAF protein is critical in the immune system and recognizes C4b and C3b fragments. It interacts with cell-associated C4b and C3b, interfering with their enzymatic conversion and preventing the formation of complement cascade amplifying convertase. CD55/DAF Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD55/DAF protein, expressed by HEK293 , with C-His labeled tag.

CD55/DAF 蛋白通过识别 C4 和 C3 激活过程中产生的 C4b 和 C3b 片段，在免疫系统中发挥着至关重要的作用。它与细胞相关的 C4b 和 C3b 多肽的相互作用干扰它们催化 C2 和因子 B 转化为酶活性 C2a 和 Bb 的能力，从而阻止 C4b2a 和 C3bBb（补体级联的扩增转化酶）的形成。这种干扰作为一种调节机制，抑制补体激活并阻止 C3 和 C5 转化酶的形成，从而减轻补体诱导的损伤。CD55/DAF 识别和调节补体成分的能力强调了其在免疫调节和保护宿主细胞免受补体介导的伤害中的关键作用。

Mouse

HEK293

C-His

Q61475 (D35-T361)

13136  [NCBI]

MIRGRAPRTRPSPPPPLLPLLSLSLLLLSPTVRGDCGPPPDIPNARPILGRHSKFAEQSKVAYSCNNGFKQVPDKSNIVVCLENGQWSSHETFCEKSCVAPERLSFASLKKEYLNMNFFPVGTIVEYECRPGFRKQPPLPGKATCLEDLVWSPVAQFCKKKSCPNPKDLDNGHINIPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNTVDWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSKSDVGQWSSPPPRCIEKSKVPTKKPTINVPSTGTPSTPQKPTTESVPNPGDQPTPQKPSTVKVSATQHVPVTKTTVRHPIRTSTDKGEPNT

Approximately 60 kDa

Greater than 90% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.