1. 重组蛋白
  2. CD Antigens Complement System
  3. NK Cell CD Proteins Stem Cell CD Proteins Erythrocyte CD Proteins Complement Regulatory Proteins
  4. CD59
  5. CD59 蛋白, Cynomolgus (HEK293, His)

CD59 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P76242
产品使用指南

CD59 蛋白是补体膜攻击复合物 (MAC) 的有效抑制剂,并在 C5b-8 阶段或之后发挥调节控制作用。CD59 的关键作用使其成为补体系统中的关键调节因子,可防止过度激活和相关的膜损伤。CD59 蛋白, Cynomolgus (HEK293, His) 是重组的 CD59 蛋白,由 HEK293 表达,带有 C-His 标签。

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描述

The CD59 protein is a potent inhibitor of the complement membrane attack complex (MAC) and exerts regulatory control at or after the C5b-8 stage. Its critical role makes CD59 a key regulator in the complement system, preventing overactivation and associated membrane damage. CD59 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD59 protein, expressed by HEK293 , with C-His labeled tag.

研究背景

CD59 蛋白作为补体膜攻击复合物 (MAC) 作用的有效抑制剂出现,在 MAC 组装的 C5b-8 阶段或之后发挥其调节影响。这一关键作用使 CD59 成为补体系统中的关键调节剂,防止过度激活以及随后与不受控制的 MAC 形成相关的膜损伤。通过针对 MAC 组装过程的特定阶段,CD59 在维持补体激活的微妙平衡中发挥着关键作用,突出了其在免疫反应中的重要性,并保护细胞完整性免受补体介导的损伤。

种属

Cynomolgus

表达系统

HEK293

标签

C-6*His

蛋白编号

G7PQF7 (L26-E101)

基因 ID
蛋白结构
N-term
CD59 (L26-E101)
Accession # G7PQF7
His
C-term
同用名
CD59 glycoprotein; HRF-20; MAC-IP; MACIF; MIRL; CD59; MIC11; MIN1; MSK21
氨基酸序列

LQCYNCPNPTTDCKTAINCSSGFDTCLIARAGLQVYNQCWKFANCNYNDISTLLKESELRYFCCKKDLCNFNEQLE

分子量

Approximately 18&14 kDa.

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD59 Protein, Cynomolgus (HEK293, His)
目录号:
HY-P76242
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