CD7 蛋白, Cynomolgus (HEK293, His)

CD7 Protein is a 40-kDa membrane protein that belongs to the immunoglobulin superfamily. CD7 is mainly expressed in T cells and natural killer (NK) cells. CD7 plays a vital role in T and NK cell functions after binding to its ligands (K12 protein and galectin-1). CD7 plays an important role in T-cell and T-cell/B-cell interactions during early lymphoid development. CD7 is also invovled in T and NK cell activation and/or adhesion^[1][2][4]. CD7 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD7 Protein, Cynomolgus (HEK293, His) is 155 a.a., with molecular weight of ~32.0 kDa.

CD7，也称为GP40。CD7 是一种 40 kDa 的膜蛋白，属于免疫球蛋白超家族。CD7 主要表达于 T 细胞和自然杀伤 (NK) 细胞。此外，CD7 在各种 T 细胞来源的恶性肿瘤患者中也高表达，如 T 急性淋巴细胞白血病 (T-ALL)、T 细胞淋巴母细胞淋巴瘤 (T-LBL) 和急性髓系白血病 (AML)^[1]。
CD7 有两个配体，K12 蛋白和 galectin-1。CD7 与其配体结合后，在 T 细胞和 NK 细胞功能中发挥着至关重要的作用^[1]。此外，CD7 在早期淋巴细胞发育过程中的 T 细胞和 T 细胞/B 细胞相互作用中发挥着重要作用^[2]。据报道，CD7 参与 HIV 1 感染和合胞体形成等过程。在小鼠中，CD7 是脂多糖诱导的炎症反应的关键分子^[3]。人类 CD7 与小鼠的氨基酸序列有约 50% 的同源性。
总之，CD7 主要表达于 T 细胞和 NK 细胞，并参与 T 细胞和 NK 细胞的激活和/或粘附^[4]。

Cynomolgus

HEK293

C-6*His

A0A2K5VA16 (A26-P180)

102124399  [NCBI]

AQEVQQSPHCTIAPVGGSVNITCSTSGELHGIYLRQLGPQPQNIIYYEDRVVPTTDKRFQGRIDFSGSQDNLTITMHHLQPSDTGTYTCQAVTEINVYGSGTLVLVTEEQSQGLHRCSDAPPTGSALPVPPTTSALPALPTASALPALPTASALP

Approximately 32.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.