CD74 蛋白, Mouse (160a.a, HEK293, His)

The CD74 protein is significantly expressed in the thymus and lymph nodes, suggesting that it plays a key role in regulating immune system function. Its presence in the thymus, a key site for T cell development, underscores its important role in overseeing key cellular processes required for immune maturation. CD74 Protein, Mouse (160a.a, HEK293, His) is the recombinant mouse-derived CD74 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD74 Protein, Mouse (160a.a, HEK293, His) is 160 a.a., with molecular weight of 25-30 kDa.

CD74 蛋白是 MHC II 类抗原加工途径不可或缺的一部分，在合成后不久通过稳定无肽 II 类 α/β 异二聚体发挥关键作用。此外，CD74 引导该复合物从内质网转运至发生肽装载到 II 类分子上的区室。除了参与抗原呈递之外，CD74 还通过与 CD44 相互作用增强 T 细胞反应。此外，CD74 充当成熟组织蛋白酶 L (CTSL) 的伴侣，通过与活性位点结合来稳定其构象。这种伴侣功能有助于在内吞区室和抗原呈递细胞 (APC) 的细胞外空间内维持成熟酶库，说明 CD74 在调节抗原加工和呈递各个阶段的免疫反应中发挥多方面的作用。

Mouse

HEK293

C-6*His

P04441-2 (Q56-L215)

16149  [NCBI]

QQQGRLDKLTITSQNLQLESLRMKLPKSAKPVSQMRMATPLLMRPMSMDNMLLGPVKNVTKYGNMTQDHVMHLLTRSGPLEYPQLKGTFPENLKHLKNSMDGVNWKIFESWMKQWLLFEMSKNSLEEKKPTEAPPKEPLDMEDLSSGLGVTRQELGQVTL

25-30 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.