2. Gene
  3. Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

Cd74 - CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ii; CLIP; DHLAG; HLADG; Ia-GAMMA

基因 ID: 16149 | 基因类型: protein coding

关于 Cd74

功能概要

Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd74 基因产物(2)

mRNA Protein Name
NM_001042605.1 NP_001036070.1 H-2 class II histocompatibility antigen gamma chain isoform 1
NM_010545.3 NP_034675.1 H-2 class II histocompatibility antigen gamma chain isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class II protein binding IPI
IPI: 通过物理相互作用推断
7985028 MGI
contributes to cytokine binding IDA
IDA: 通过直接分析推断
18056708 MGI
enables cytokine receptor activity IMP
IMP: 通过突变表型推断
12782713 MGI
enables nitric-oxide synthase binding IPI
IPI: 通过物理相互作用推断
18003616 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7985028 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within antigen processing and presentation IDA
IDA: 通过直接分析推断
3864916 MGI
acts upstream of or within antigen processing and presentation IMP
IMP: 通过突变表型推断
9432982 MGI
acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class II IMP
IMP: 通过突变表型推断
7679955 MGI
acts upstream of or within chaperone cofactor-dependent protein refolding IDA
IDA: 通过直接分析推断
7985028 MGI
acts upstream of or within chaperone cofactor-dependent protein refolding IMP
IMP: 通过突变表型推断
7679955 MGI
acts upstream of or within defense response IMP
IMP: 通过突变表型推断
8098731 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: 通过突变表型推断
7679955 MGI
acts upstream of or within intracellular protein transport IDA
IDA: 通过直接分析推断
11754812 MGI
acts upstream of or within intracellular protein transport IMP
IMP: 通过突变表型推断
7679955 MGI
involved in macrophage migration inhibitory factor signaling pathway IDA
IDA: 通过直接分析推断
19413900 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
17045821 MGI
acts upstream of or within negative regulation of T cell differentiation IMP
IMP: 通过突变表型推断
7679955 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
17045821 MGI
involved in negative regulation of mature B cell apoptotic process IMP
IMP: 通过突变表型推断
18056708 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
7679955 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
12782713 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: 通过突变表型推断
7679955 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IDA
IDA: 通过直接分析推断
19413900 MGI
involved in positive regulation of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
12782713 MGI
involved in positive regulation of dendritic cell antigen processing and presentation IDA
IDA: 通过直接分析推断
18003616 MGI
involved in positive regulation of macrophage cytokine production IDA
IDA: 通过直接分析推断
19413900 MGI
involved in positive regulation of neutrophil chemotaxis IDA
IDA: 通过直接分析推断
19413900 MGI
involved in positive regulation of type 2 immune response IMP
IMP: 通过突变表型推断
11823488 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: 通过突变表型推断
7679955 MGI
involved in protein stabilization IMP
IMP: 通过突变表型推断
11483509 MGI
acts upstream of or within protein-containing complex assembly IDA
IDA: 通过直接分析推断
7985028 MGI
involved in response to type II interferon IDA
IDA: 通过直接分析推断
32855215 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
11854359 MGI
part of MHC class II protein complex IDA
IDA: 通过直接分析推断
7985028 MGI
part of NOS2-CD74 complex IDA
IDA: 通过直接分析推断
18003616 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
11854359 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
7679955 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
12417635 MGI
located in late endosome IDA
IDA: 通过直接分析推断
11483509 MGI
located in lysosome IDA
IDA: 通过直接分析推断
11483509 MGI
part of macrophage migration inhibitory factor receptor complex IDA
IDA: 通过直接分析推断
12782713 MGI
located in multivesicular body IDA
IDA: 通过直接分析推断
11854359 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
8294875 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
8098731 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

H-2 class II histocompatibility antigen gamma chain

HLA-DR-GAMMA

Ia-associated invariant chain

MHC class II-associated invariant chain

class II-associated invariant chain peptide

dinucleotide microsatellite

histocompatibility: class II antigens, gamma chain of

ia antigen-associated invariant chain

i

重组 Cd74 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72710 CD74 Protein, Mouse (160a.a, HEK293, His) P04441-2 (Q56-L215) ≥95%
HY-P78262 CD74 Protein, Mouse (224a.a, HEK293, His) P04441-1 (Q56-L279) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99731 Milatuzumab Inhibitor 99.39% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N15169 BG-136 Activator / 否
HY-N2245 Schisandrone Inhibitor 99.85% 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990728 Bezetabart Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd74 NCBI NCBI:972
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