CD81 蛋白, Mouse (HEK293, Fc)

The CD81 protein has important effects on cellular processes and is involved in CD19 receptor trafficking on activated B cells. This facilitates CD19-CR2 and B cell receptor complex assembly, lowering the antigen dose threshold for B cell clonal expansion. CD81 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD81 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of CD81 Protein, Mouse (HEK293, Fc) is 86 a.a., with molecular weight of ~36.1 kDa.

CD81 是一种在各种细胞过程中发挥关键作用的蛋白质。它参与活化 B 细胞表面 CD19 受体的运输和区室化。这有利于 CD19-CR2 和 B 细胞受体复合物的组装，从而降低触发 B 细胞克隆扩增和免疫反应所需的抗原阈值剂量。在 T 细胞中，CD81 与 CD4 或 CD8 辅助受体结合，有助于确定 B 细胞突触的成熟状态。它还促进 CD3 在免疫突触中的定位，这对于 T 细胞激活和共刺激是必需的。CD81 可以充当细胞-细胞融合过程的正调节因子和负调节因子。在成肌细胞中，它与 CD9 和 PTGFRN 结合，抑制肌肉再生过程中的肌管融合。在巨噬细胞中，CD81 阻止融合成多核巨细胞和破骨细胞。它还调节精卵融合，并可能参与顶体反应。CD81 参与细胞内的蛋白质运输并调节 T 细胞的细胞内 dNTP 水平。此外，它在巨噬细胞的整合素依赖性迁移中发挥作用，并且是疟疾感染期间肝细胞中约氏疟原虫的感染性所特别需要的。

Mouse

HEK293

N-mFc

P35762 (K116-K201)

12520  [NCBI]

Approximately 36.1 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.