CD93/C1qR1 蛋白, Rat (HEK293, His)

The CD93/C1qR1 protein is a receptor or component of a larger complex that is critical in immune recognition and response. It acts as a receptor for C1q, mannose-binding lectin (MBL2), and pulmonary surfactant protein A (SPA), suggesting a role in interactions with multiple immune components. CD93/C1qR1 Protein, Rat (HEK293, His) is the recombinant rat-derived CD93/C1qR1 protein, expressed by HEK293 , with C-His labeled tag.

CD93/C1qR1 蛋白被确定为受体或较大受体复合物的组成部分，在免疫识别和反应中发挥着关键作用。它是 C1q、甘露糖结合凝集素 (MBL2) 和肺表面活性蛋白 A (SPA) 的受体，表明它参与识别免疫系统的各个组成部分并与之相互作用。CD93/C1qR1 可能有助于增强单核细胞和巨噬细胞的吞噬作用，特别是在与可溶性防御胶原蛋白相互作用时。此外，它还涉及细胞间粘附的潜在作用，强调了其多功能性。与 C1QBP 的相互作用表明可能与细胞表面 C1q 相关，进一步凸显了 CD93/C1qR1 在免疫相关过程中的复杂性。CD93/C1qR1 的多种相互作用和功能强调了其在协调免疫反应和细胞相互作用中的重要性。

Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED₅₀ for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

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  Measured by its ability to enhance TNF-alpha secretion by THP 1 human acute monocytic leukemia cells. The ED₅₀ for this effect is 6.393 μg/mL, corresponding to a specific activity is 156.421 U/mg.

Rat

HEK293

C-10*His

Q9ET61 (D24-K571)

84398  [NCBI]

DSEAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQEALAQLLKTKAPSETKIGKFWIGLQREKGKCTYHDLPMKGFSWVGGGEDTTYSNWYKASKSSCISKRCVSLILDLSLKPHPSHLPKWHESPCGTPDAPGNSIEGFLCKFNFKGMCSPLALGGPGQLTYTTPFQATTSSLKAVPFASVANVVCGDEAESKTNYYLCKETTAGVFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCHCPRGYQLDSSQVHCVDIDECEDSPCDQECINTPGGFHCECWVGYQSSGSKEEACEDVDECTAAYSPCAQGCTNTDGSFYCSCKEGYIMSGEDSTQCEDIDECLGNPCDTLCINTDGSFRCGCPAGFELAPNGVSCTRGSMFSELPARPPQKEDKGDGKESTVPLTEMPGSLNGSKDVSNRAQTTDLSIQSDSSTASVPLEIEVSSEASDVWLDLGTYLPTTSGHSQPTHEDSVPAHSDSDTDGQK

Approximately 75-90 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.