CD96 蛋白, Human (HEK293, His)

CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (HEK293, His) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of CD96 Protein, Human (HEK293, His) is 482 a.a., with molecular weight of 120-130 kDa.

CD96 蛋白似乎在免疫反应后期的粘附相互作用中发挥作用，可能涉及活化的 T 细胞和 NK 细胞。它通过与靶细胞上存在的 PVR 相互作用来促进 NK 细胞与靶标的粘附。CD96 可能在 T 细胞和 NK 细胞使用整合素和选择素穿透内皮细胞后的一个阶段发挥作用，积极与患病细胞结合并在炎症区域内导航。在结构上，CD96 通过二硫键形成同二聚体，并与 PVR 特异性相互作用，表明它参与了炎症和感染期间免疫反应至关重要的细胞间相互作用。

Human

HEK293

C-6*His

P40200-2 (V22-M503)

10225  [NCBI]

VWEKTVNTEENVYATLGSDVNLTCQTQTVGFFVQMQWSKVTNKIDLIAVYHPQYGFYCAYGRPCESLVTFTETPENGSKWTLHLRNMSCSVSGRYECMLVLYPEGIQTKIYNLLIQTHVTADEWNSNHTIEIEINQTLEIPCFQNSSSKISSEFTYAWSVEDNGTQETLISQNHLISNSTLLKDRVKLGTDYRLHLSPVQIFDDGRKFSCHIRVGPNKILRSSTTVKVFAKPEIPVIVENNSTDVLVERRFTCLLKNVFPKANITWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSNKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEISSTDPPLSVTESTLDTQPSPASSVSPARYPATSSVTLVDVSALRPNTTPQPSNSSMTTRGFNYPWTSSGTDTKKSVSRIPSETYSSSPSGAGSTLHDNVFTSTARAFSEVPTTANGSTKTNHVHITGIVVNKPKDGM

120-130 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.