1. 重组蛋白
  2. Immune Checkpoint Proteins CD Antigens
  3. Inhibitory Checkpoint Molecules NK Cell CD Proteins Macrophage CD Proteins Stem Cell CD Proteins Cell Adhesion-related CD Proteins
  4. CD96
  5. CD96 蛋白, Human (HEK293, mFc)

CD96 蛋白, Human (HEK293, mFc)

目录号: HY-P78420
COA 产品使用指南

CD96 在免疫反应的后期促进活化的 T 细胞和 NK 细胞之间的粘附相互作用。它通过与靶细胞上的 PVR 相互作用,促进 NK 细胞与靶细胞之间的粘附。CD96 蛋白, Human (HEK293, mFc) 是重组的 CD96 蛋白,由 HEK293 表达,带有 C-mFc 标签。CD96 蛋白, Human (HEK293, mFc) 全长 482 个氨基酸,分子量为 120-160 kDa。

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规格 价格 是否有货 数量
20 μg ¥1100 In-stock
50 μg ¥2400 In-stock
100 μg   询价  

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  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

CD96 promotes adhesive interactions between activated T cells and NK cells in the late stages of the immune response. It promotes the adhesion between NK cells and target cells by interacting with PVR on target cells. CD96 Protein, Human (HEK293, mFc) is the recombinant human-derived CD96 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of CD96 Protein, Human (HEK293, mFc) is 482 a.a., with molecular weight of 120-160 kDa.

研究背景

CD96 蛋白似乎在免疫反应后期的粘附相互作用中发挥作用,可能涉及活化的 T 细胞和 NK 细胞。它通过与靶细胞上存在的 PVR 相互作用来促进 NK 细胞与靶标的粘附。CD96 可能在 T 细胞和 NK 细胞使用整合素和选择素穿透内皮细胞后的一个阶段发挥作用,积极与患病细胞结合并在炎症区域内导航。在结构上,CD96 通过二硫键形成同二聚体,并与 PVR 特异性相互作用,表明它参与了炎症和感染期间免疫反应至关重要的细胞间相互作用。

生物活性

1. Immobilized Human CD96, mFc Tag at 5 μg/mL (100 μl/Well) on the plate. Dose response curve for Human CD155, hFc Tag with the EC50 of 0.21 μg/mL determined by ELISA.
2. Immobilized Human CD96, mFc Tag at 2 μg/mL (100 μl/Well) on the plate. Dose response curve for Anti-CD96 Antibody, hFc Tag with the EC50 of ≤25.9 ng/mL determined by ELISA.

种属

Human

表达系统

HEK293

标签

C-mFc

蛋白编号

P40200-2 (V22-M503)

基因 ID
蛋白结构
N-term
CD96 (V22-M503)
Accession # P40200-2
mFc
C-term
同用名
CD96 molecule; CD96; DKFZp667E2122; TACTILE
分子量

120-160 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

性状

无菌粉末

组分

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
CD96 Protein, Human (HEK293, mFc)
目录号:
HY-P78420
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