CDKN2C 蛋白, Human (His)

The CDKN2C protein (also known as p18) interacts strongly with CDK6 and weakly with CDK4. Its functional effects inhibit cell growth and proliferation and are significantly related to the presence of endogenous retinoblastoma protein RB. CDKN2C Protein, Human (His) is the recombinant human-derived CDKN2C protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDKN2C Protein, Human (His) is 168 a.a., with molecular weight of ~17.0 kDa.

CDKN2C 蛋白（也称为 p18）与 CDK6 具有较强的相互作用，与 CDK4 的相互作用较弱。其功能影响体现在抑制细胞生长和增殖，并且与内源性视网膜母细胞瘤蛋白 RB 的存在存在显着相关性。p18 和 CDK6 之间异二聚体复合物的形成强调了其在细胞周期进程中作为调节剂的作用。这种相互作用凸显了 CDKN2C 在调节关键细胞过程中的重要性，特别是在控制细胞周期蛋白依赖性激酶的活性和影响细胞增殖动力学方面。

Human

E. coli

N-6*His

P42773 (M1-Q168)

1031  [NCBI]

MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQVMKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNEGNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANGAGGATNLQ

Approximately 17.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.